Publications by authors named "Maoyu Ye"
SO activates Th17 cells through the JAK1,2/STAT3 signaling pathway.
Int Immunopharmacol
December 2024
Article Synopsis
- The study looked at how a substance called SO affects certain immune cells in people with allergic rhinitis (AR) to find better treatments.
- The researchers tested blood samples from 15 AR patients and 15 healthy people to see how SO and a drug called Ruxolitinib changed the immune cell balance and some important proteins.
- The results showed that SO boosted immune cell activity in both AR patients and healthy individuals, but using Ruxolitinib reduced some of these effects, pointing to a possible way to treat AR.
Article Synopsis
- Chronic rhinosinusitis with nasal polyps (CRSwNP) is recurrent, and this study aimed to identify biomarkers for patients with recurrent CRSwNP (rCRSwNP) by analyzing serum proteins in two independent cohorts.
- Serum proteomic profiling revealed significant differences in protein levels, identifying CD163 and TGF-β1 as elevated and CD109 as decreased in rCRSwNP patients, indicating their association with the risk of postoperative recurrence.
- In vitro experiments confirmed that TGF-β1 promotes a cellular change (epithelial-mesenchymal transition) in nasal epithelial cells, while CD109 appears to counteract this process, revealing a potential therapeutic target for controlling rCRSwNP.
Background: Individuals with eosinophilic chronic rhinosinusitis with nasal polyps(eCRSwNP) exhibited worse outcomes and higher postoperative recurrence rates. This study aimed to identify biomarkers that can aid in the early differentiation of eCRSwNP and enhance our comprehension of its pathophysiology.
Methods: We recruited two independent cohorts.
Objective: To determine the predictive value of the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), neutrophil-to-eosinophil ratio (NER), lymphocyte-to-eosinophil ratio (LER), monocyte-to-eosinophil ratio (MER), systemic inflammatory response index (SIRI), and ratio of inflammatory cells before and after treatment for predicting survival in advanced nasopharyngeal carcinoma (NPC) and to provide a reference for treatment.
Methods: A retrospective review of 70 patients was performed. Serological indexes were obtained by drawing blood before and after systemic therapy.
Background: Hypopharyngeal carcinoma is the worst type of head and neck squamous cell carcinoma. It is necessary to identify the key molecular targets related to the carcinogenesis and development of hypopharyngeal carcinoma.
Methods: Differentially expressed lncRNAs in hypopharyngeal carcinoma were selected by microarray, and lncRNA-associated proteins were found by RIP assay.
Background: Exposure to atmospheric pollutants is closely associated with the occurrence of allergic rhinitis (AR). However, the role of sulfur dioxide (SO) in promoting allergic inflammation in AR is poorly understood. Our study aims to investigate the effect of SO on allergic inflammation in house dust mite (HDM)-sensitized mice.
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