Temporary alleviation of MAPK by arbutin alleviates oxidative damage in the retina and ARPE-19 cells.

Dry age-related macular degeneration (AMD) is one of the main diseases that causes blindness in humans, and the number of cases is increasing yearly. However, effective treatments are unavailable, and arbutin (ARB) has been reported to have antioxidant, anti-inflammatory, and anti-aging effects in other age-related diseases. However, whether ARB can be used to treat dry AMD remains unknown.

Type I Collagen-Adhesive and ROS-Scavenging Nanoreactors Enhanced Retinal Ganglion Cell Survival in an Experimental Optic Nerve Crush Model.

Traumatic optic neuropathy (TON) is a severe condition characterized by retinal ganglion cell (RGC) death, often leading to irreversible vision loss, and the death of RGCs is closely associated with oxidative stress. Unfortunately, effective treatment options for TON are lacking. To address this, catalase (CAT) is encapsulated in a tannic acid (TA)/poly(ethylenimine)-crosslinked hollow nanoreactor (CAT@PTP), which exhibited enhanced anchoring in the retina due to TA-collagen adhesion.

Long-acting acid-sensitive ketal-linked dexamethasone microcrystals for treating experimental autoimmune uveitis.

Corticosteroids have for some time been used as first-line drugs for the topical treatment of noninfectious uveitis, but poor ocular bioavailability and the rapid clearance of eye drops necessitate frequent dosing, reducing patient compliance. In this study, we used an acid-sensitive stearoxyl-ketal-dexamethasone pro-drug microcrystals (SKD MCs), which is consistently safe and effective in the control of uveitis inflammation in rats. We used a rat model of experimental autoimmune uveitis (EAU) to evaluate the effects of SKD MCs in terms of clinical manifestations, molecular biology, pathological histology, and visual electrophysiology compared to dexamethasone sodium phosphate injection or phosphate-buffered saline.

O oxidation combined with semi-dry method for simultaneous desulfurization and denitrification of sintering/pelletizing flue gas.

With the vigorous development of China's iron and steel industry and the introduction of ultra-low emission policies, the emission of pollutants such as SO and NO has received unprecedented attention. Considering the increase of the proportion of semi-dry desulfurization technology in the desulfurization process, several semi-dry desulphurization technologies such as flue gas circulating fluidized bed (CFB), dense flow absorber (DFA) and spray drying absorption (SDA) are briefly summarized. Moreover, a method for simultaneous treatment of SO and NO in sintering/pelletizing flue gas by O oxidation combined with semi-dry method is introduced.

Simultaneous removal of SO and NO using a spray dryer absorption (SDA) method combined with O oxidation for sintering/pelleting flue gas.

Based on the demand of sintering/pelleting flue gas ultra-low emission, a semi-dry method using a spray dryer absorber (SDA) combined with O oxidation was proposed for simultaneous removal of SO and NO. Effects of O injection site, O/NO molar ratio, and spray tower temperature on the removal efficiencies were investigated. It was revealed that both desulfurization and denitrification efficiencies could reach to 85% under the conditions of setting O injection site inside of tower, O/NO molar ratio 1.

Simultaneous Removal of NO and SO by MgO Combined with O Oxidation: The Influencing Factors and O Consumption Distributions.

Simultaneous removal of NO and SO by MgO combined with O oxidation was studied. The effects of the O/NO molar ratio, oxidation temperature, and oxidation residence time on NO decomposition and O consumption distributions were systematically illustrated, which is of great significance for improving NO removal efficiency and reducing O consumption in practical application. When the O/NO molar ratio was greater than 1.