Publications by authors named "Maoye Tian"
Engineered platelet cell motors for boosted cancer radiosensitization.
J Colloid Interface Sci
March 2024
Design of engineered cells to target and deliver nanodrugs to the hard-to-reach regions has become an exciting research area. However, the limited penetration and retention of cell-based carriers in tumor tissue restricted their therapeutic efficiency. Inspired by the enhanced delivery behavior of mobile micro/nanomotors, herein, urease-powered platelet cell motors (PLT@Au@Urease) capable of active locomotion, tumor targeting, and radiosensitizers delivery were designed for boosting radiosensitization.
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- Selenium (Se) and tellurium (Te) nanomaterials have unique chain-like structures and interesting properties but the unclear catalytic mechanisms hinder their biocatalytic advancements.
- * Researchers created chitosan-coated Se nanozymes that show 23 times more antioxidative activity compared to Trolox, while Te nanozymes demonstrated stronger prooxidative effects.
- * The study reveals that Se nanozymes help clear reactive oxygen species (ROS) using a specific mechanism, while Te nanozymes increase ROS production, affecting the survival of γ-irradiated mice differently by either inhibiting or promoting oxidation.
Article Synopsis
- * Researchers developed two types of cerium-based metal organic frameworks (Ce-MOFs) that mimic SOD's ability to scavenge superoxide radicals and provide protection against radiation.
- * The more effective CeBTC nanozymes showed promising results in reducing ROS, preventing cell damage from γ-ray radiation, and improving overall survival and recovery in irradiated mice, making them a potential new treatment for radiation damage and ROS-related diseases.