Droplet-based high-throughput 3D genome structure mapping of single cells with simultaneous transcriptomics.

Single-cell three-dimensional (3D) genome techniques have advanced our understanding of cell-type-specific chromatin structures in complex tissues, yet current methodologies are limited in cell throughput. Here we introduce a high-throughput single-cell Hi-C (dscHi-C) approach and its transcriptome co-assay (dscHi-C-multiome) using droplet microfluidics. Using dscHi-C, we investigate chromatin structural changes during mouse brain aging by profiling 32,777 single cells across three developmental stages (3 months, 12 months, and 23 months), yielding a median of 78,220 unique contacts.

ESCCdb: A comprehensive database and key regulator exploring platform based on cross dataset comparisons for esophageal squamous cell carcinoma.

Esophageal cancer is the seventh most prevalent and the sixth most lethal cancer. Esophageal squamous cell carcinoma (ESCC) is one of the major esophageal cancer subtypes that accounts for 87 % of the total cases. However, its molecular mechanism remains unclear.

Precise Synthesis of Fe-N Sites with High Activity and Stability for Long-Life Lithium-Sulfur Batteries.

Precisely tuning the coordination environment of the metal center and further maximizing the activity of transition metal-nitrogen carbon (M-NC) catalysts for high-performance lithium-sulfur batteries are greatly desired. Herein, we construct an Fe-NC material with uniform and stable Fe-N coordination structure. The theoretical and experimental results indicate that the unsaturated Fe-N center can act as a multifunctional site for anchoring lithium polysulfides (LiPSs), accelerating the redox conversion of LiPSs and reducing the reaction energy barrier of LiS decomposition.

Redox Mediator: A New Strategy in Designing Cathode for Prompting Redox Process of Li-S Batteries.

The multistep redox reactions of lithium-sulfur batteries involve undesirably complex transformation between sulfur and LiS, and it is tough to spontaneously fragmentate polysulfides into shorter chains LiS originating from the sluggish redox kinetics of soluble polysulfide intermediates, causing serious polarization and consumption of sulfur. In this work, 3,4,9,10-perylenetetracarboxylic diimide (PTCDI)/G is employed as sulfur host to accelerate the conversion process between polysulfides and sulfur, which could facilitate the process of both charging and discharging. Moreover, PTCDI has strong adsorption capacity with polysulfides to restrain shuttle effect, resulting in promotional kinetics and cycle stability.

A Class of Catalysts of BiOX (X = Cl, Br, I) for Anchoring Polysulfides and Accelerating Redox Reaction in Lithium Sulfur Batteries.

The lithium-sulfur battery system contains a complex reaction process of sulfur involving multielectron reactions and phase conversions. Moreover, the diffusion of intermediate polysulfides during reduction and sluggish kinetic conversion of polysulfides into insoluble LiS still plague the use of Li-S batteries. Herein, BiOX was employed as sulfur host material in Li-S batteries, which could integrate suppression of the shuttle effect and promote kinetics redox reactions of lithium polysulfides.

Blocking Polysulfide with CoB@CNT via "Synergetic Adsorptive Effect" toward Ultrahigh-Rate Capability and Robust Lithium-Sulfur Battery.

Li-S batteries have attracted great interest as the next-generation secondary batteries due to their high energy density, being environmentally friendly, and low price. However, the road to commercialization of lithium-sulfur batteries remains limited owing to the "shuttle effect" of soluble polysulfides, which results in the inferior cycle stability. Herein, a potent functional separator is developed to restrain the "shuttle effect" by coating CoB@carbon nanotube layer on the commercialized polypropylene separator.

SnS /SnO Heterostructures towards Enhanced Electrochemical Performance of Lithium-Sulfur Batteries.

Lithium-sulfur (Li-S) batteries have been recognized as outstanding candidates for energy storage systems due to their superiority in terms of energy density. To meet the requirements for practical use, it is necessary to develop an effective method to realize Li-S batteries with high sulfur utilization and cycle stability. Here, a strategy to construct heterostructure composites as cathodes for high performance Li-S batteries is presented.

Ion-Selective Prussian-Blue-Modified Celgard Separator for High-Performance Lithium-Sulfur Battery.

Application of Li-S batteries has been restricted because of their major problem, that is, shuttling of soluble polysulfides between electrodes, which results in serious capacity fading. For the development of high-performance Li-S batteries, we first time utilize a simple growth method to introduce a Prussian blue (PB)-modified Celgard separator as an ion-selective membrane. The unique structure of PB could effectively suppress the shuttle of polysulfides but scarcely affect the transfer ability of lithium ions, which is beneficial to achieve high sulfur conversion efficiency and capacity retention.

A Conductive Ni P Nanoporous Composite with a 3D Structure Derived from a Metal-Organic Framework for Lithium-Sulfur Batteries.

Sulfur cathodes have attracted significant attention as next-generation electrode material candidates due to their considerable theoretical energy density. The main challenge in developing long-life Li-S batteries is to simultaneously suppress the shuttle effect and high areal mass loading of sulfur required for practical applications. To solve this problem, we have designed a novel nickel phosphide nanoporous composite derived from metal-organic frameworks (MOFs) as sulfur host materials.

Long-Life Lithium-Sulfur Battery Derived from Nori-Based Nitrogen and Oxygen Dual-Doped 3D Hierarchical Biochar.

Due to restrictions on the low conductivity of sulfur and soluble polysulfides during discharge, lithium sulfur batteries are unsuitable for further large scale applications. The current carbon based cathodes suffer from poor cycle stability and high cost. Recently, heteroatom doped carbons have been considered as a settlement to enhance the performance of lithium sulfur batteries.