Within-Host Resistance and Virulence Evolution of a Hypervirulent Carbapenem-Resistant ST11 Under Antibiotic Pressure.

Background: Hypervirulent carbapenem-resistant (hv-CRKP) has recently aroused an extremely severe health challenge and public concern. However, the underlying mechanisms of fitness costs that accompany antibiotic resistance acquisition remain largely unexplored. Here, we report a hv-CRKP-associated fatal infection and reveal a reduction in virulence due to the acquisition of aminoglycoside resistance.

Comparative Proteomics Demonstrates Altered Metabolism Pathways in Cotrimoxazole- Resistant and Amikacin-Resistant Isolates.

Antibiotic resistance (AMR) has always been a hot topic all over the world and its mechanisms are varied and complicated. Previous evidence revealed the metabolic slowdown in resistant bacteria, suggesting the important role of metabolism in antibiotic resistance. However, the molecular mechanism of reduced metabolism remains poorly understood, which inspires us to explore the global proteome change during antibiotic resistance.

Clinical and Molecular Characteristics of Carbapenem-Resistant Hypervirulent Isolates in a Tertiary Hospital in Shanghai, China.

Background: The convergence of carbapenem-resistance and hypervirulence in has led to a significant public health challenge. In recent years, there have been more and more reports on carbapenem-resistant hypervirulent (CR-hvKP) isolates.

Materials And Methods: Clinical data of patients infected with CR-hvKP from January 2019 to December 2020 in a tertiary hospital were retrospectively evaluated.