Mechanisms of Mt.b Ag85B-Fc fusion protein against allergic asthma in mice by intranasal immunization.

Ag85B, the primary component of the Ag85 complex and an early secreted protein by Mycobacterium tuberculosis, has shown potential for the treatment of allergic asthma (AA) when used as a Fc-fusion protein. Administered via nasal immunization, Ag85B-Fc fusion protein significantly alleviated airway inflammation and reduced the proportions of some anaphylaxis related cells in lungs, with no significant histopathological injury to major organs in ovalbumin (OVA)-induced AA model mice. To investigate the underlying immune regulatory mechanisms of Ag85B protein, integrated proteomics and transcriptomics analyses were conducted, identifying the complement and coagulation cascades, and phagosomes as the two significantly enriched pathways at both gene and protein levels.

Development of an innovative reusable terahertz biosensor platform integrated graphene and all-silicon groove for detecting cancer cells in aqueous environments.

The label-free detection and analysis of cancer cells using portable biosensing devices is crucial and promising. In this study, a novel reusable biosensing platform with a microfluidic-like based on terahertz plasmonic metasurfaces utilizing graphene integrated with an all-silicon groove for detecting liquid live cancer cells was developed. The proposed biosensor platform stands out because it can differentiate between the concentrations of three types of cancer cells by monitoring changes in resonance intensity and phase difference.

Ultrasensitive optical modulation in hybrid metal-perovskite and metal-graphene metasurface THz devices.

Implementation of efficient terahertz (THz) wave control is essential for THz technology development for applications including sixth-generation communications and THz sensing. Therefore, realization of tunable THz devices with large-scale intensity modulation capabilities is highly desirable. By integrating perovskite and graphene with a metallic asymmetric metasurface, two ultrasensitive devices for dynamic THz wave manipulation through low-power optical excitation are demonstrated experimentally here.

MYB112 connects light and circadian clock signals to promote hypocotyl elongation in Arabidopsis.

Ambient light and the endogenous circadian clock play key roles in regulating Arabidopsis (Arabidopsis thaliana) seedling photomorphogenesis. PHYTOCHROME-INTERACTING FACTOR 4 (PIF4) acts downstream of both light and the circadian clock to promote hypocotyl elongation. Several members of the R2R3-MYB transcription factor (TF) family, the most common type of MYB TF family in Arabidopsis, have been shown to be involved in regulating photomorphogenesis.

Advances in terahertz metasurface graphene for biosensing and application.

Based on the extraordinary electromagnetic properties of terahertz waves, such as broadband, low energy, high permeability, and biometric fingerprint spectra, terahertz sensors show great application prospects in the biochemical field. However, the sensitivity of terahertz sensing technology is increasingly required by modern sensing demands. With the development of terahertz technology and functional materials, graphene-based terahertz metasurface sensors with the advantages of high sensitivity, fingerprint identification, nondestructive and anti-interference are gradually gaining attention.

Identification of Circular RNA Profiles in the Liver of Diet-Induced Obese Mice and Construction of the ceRNA Network.

Obesity is a major risk factor for cardiovascular, cerebrovascular, metabolic, and respiratory diseases, and it has become an important social health problem affecting the health of the population. Obesity is affected by both genetic and environmental factors. In this study, we constructed a diet-induced obese C57BL/6J mouse model and performed deep RNA sequencing (RNA-seq) on liner-depleted RNA extracted from the liver tissues of the mice to explore the underlying mechanisms of obesity.

Silver nanoparticles-integrated terahertz metasurface for enhancing sensor sensitivity.

A silver nanoparticles (AgNPs)-integrated terahertz (THz) metasurface sensor was presented and applied to enhance the sensitivity of substance detection. Simulations and experiments were conducted to study the influence of AgNPs on the sensor performance. The enhancement of the local electric field excited by AgNPs can substantially strengthen the interaction between the THz waves and analytes, thereby increasing detection sensitivity.

Graphene-integrated toroidal resonance metasurfaces used for picogram-level detection of chlorothalonil in the terahertz region.

Toroidal dipole resonance can significantly reduce radiation loss of materials, potentially improving sensor sensitivity. Generally, toroidal dipole response is suppressed by electric and magnetic dipoles in natural materials, making it difficult to observe experimentally. However, as 2D metamaterials, metasurfaces can weaken the electric and magnetic dipole, enhancing toroidal dipole response.

Multispectral higher-order Fano resonant metasurface based on periodic twisted DNA-like split ring arrays with three modulation methods.

The active modulation of the Fano resonance is rare but desirable. However, recent studies mostly focused on a single modulation method and few reported the use of three photoelectric control methods. A tunable graphene DNA-like metamaterial modulator with multispectral Fano resonance is demonstrated.

Dual control of multi-band resonances with a metal-halide perovskite-integrated terahertz metasurface.

The phenomenon of multi-resonant Fano resonances is important for the design of biosensors and communication fields. There are very few studies reporting the multi-band Fano resonance metamaterials with more than three resonance frequencies, or the tunable optical metamaterials to control the multi-band Fano resonance characteristics. Here, we report dual control of multi-band Fano resonances with a metal-halide perovskite-integrated terahertz metasurface by lasers and an electrical field.

Time-frequency joint mappings of a terahertz metasurface for multi-dimensional analysis of biological cells.

Traditional fast Fourier transform is used to extract the frequency component at the cost of losing the time domain, which is critical for metasurface biosensing. In this Letter, a more comprehensive algorithm, continuous wavelet transform (CWT), to process signals from THz time-domain spectroscopy is introduced. By comparing the metasurface-enhanced 2D time-frequency mappings (TFMs) of HaCaT and HSC3 cells, the two types of biological cells can be clearly differentiated, showing the great potential of CWT in the label-free recognition of biological cells.

Ultrasensitive, light-induced reversible multidimensional biosensing using THz metasurfaces hybridized with patterned graphene and perovskite.

Biosensors based on terahertz (THz) metasurfaces have recently attracted widespread attention. However, few have been reported so far because it is a challenge to achieve ultrasensitive multidimensional detection in the THz spectrum. Here, we propose a novel THz biosensor that consists of a metasurfaces and a metal oxide semiconductor-like structure (MOSLS), which is based on patterned graphene-polyimide-perovskite.

Development and Validity Test of Social Attachment Multidimensional Scale.

Social attachment can explain well the bond between users and social media, but existing research lacks measures of social attachment scales. To this end, this study takes attachment theory as the basis for scale development. On the basis of the development of multidimensional scales for adult, brand, and local attachment, it combines existing relevant studies on social attachment, selects three representative social media such as TikTok, WeChat, and MicroBlog as theoretical samples, explores the concept and structure of social attachment, and develops a social attachment scale through qualitative interviews and open-ended questionnaires.

Dual-Stimulus Control for Ultra-Wideband and Multidimensional Modulation in Terahertz Metasurfaces Comprising Graphene and Metal Halide Perovskites.

Perovskites and graphene are receiving a meteoric rise in popularity in the field of active photonics because they exhibit excellent optoelectronic properties for dynamic manipulation of light-matter interactions. However, challenges still exist, such as the instability of perovskites under ambient conditions and the low Fermi level of graphene in experiments. These shortcomings limit the scope of applications when they are used alone in advanced optical devices.

Accessing the Influence of Perceived Value on Social Attachment: Developing Country Perspective.

Perceived value has a positive impact on users' social attachment in social media usage contexts and is a topic at the forefront of current research in consumer behavior. Although studies have begun to investigate the factors influencing social attachment, there is a lack of research on how perceived value affects social attachment. Therefore, this study uses privacy concern theory, to build a theoretical model with moderated and mediation roles, using Chinese Tik Tok users as data and survey sample, and applying Mplus7.

Understanding the Mechanism of Social Attachment Role in Social Media: A Qualitative Analysis.

Qualitative research method was used to explore the formation and development of the attachment relationship between users and social media in the process of using social media. Based on the attachment theory, this study selected three representative social media platforms, namely, TikTok, WeChat, and MicroBlog, as theoretical samples, and this study adopted NVivo12.0 to root, theorize, and construct the original data.

Oleic acid induces A7r5 cell proliferation and migration associated with increased expression of HGF and p‑p38.

The phenotypes and mechanisms underlying the proliferation and migration of vascular smooth muscle cells (VSMCs) induced by oleic acid (OA) are not completely understood. Therefore, the aim of the present study was to further elucidate the effects of OA on the proliferation and migration of VSMCs. Using A7r5 cells, the hepatocyte growth factor (HGF) inhibitor PHA665752 and the p38 MAPK inhibitor SB203580 were utilized, and Cell Counting Kit‑8 (CCK‑8) assays, Transwell assays, flow cytometry, ELISAs, western blotting and reverse transcription‑quantitative PCR (RT‑qPCR) were conducted to assess the effects of OA.

Graphene-bridged topological network metamaterials with perfect modulation applied to dynamic cloaking and meta-sensing.

Perfect state transfer of the bus topological system enables the sharing of information or excitation between nodes. Herein we report groundbreaking research on the transfer of the graphene-bridged bus topological network structure to an electromagnetic metamaterial setting, named "bus topological network metamaterials (TNMMs)." Correspondingly, the electromagnetic response imprints onto the topological excitation.

Heart Rate and Heart Rate Difference Predicted the Efficacy of Metoprolol on Postural Tachycardia Syndrome in Children and Adolescents.

Objective: To evaluate the ability of heart rate (HR) and HR difference during head-up tilt test (HUTT) and to predict clinical improvement related to metoprolol treatment in children and adolescents with postural tachycardia syndrome (POTS).

Study Design: This was a retrospective cohort study. A total of 53 subjects (27 male, aged 6-12 years old, mean age 11.

Position-guided Fano resonance and amended GaussAmp model for the control of slow light in hybrid graphene-silicon metamaterials.

Position-guided Fano resonance is observed in hybrid graphene-silicon metamaterials. An outstanding application of such resonance is slow-light metadevices. The maximum group delay is 9.

The Antibody-Free Recognition of Cancer Cells Using Plasmonic Biosensor Platforms with the Anisotropic Resonant Metasurfaces.

It is vital and promising for portable and disposable biosensing devices to achieve on-site detection and analysis of cancer cells. Although traditional labeling techniques provide an accurate quantitative measurement, the complicated cell staining and high-cost measurements limit their further development. Here, we demonstrate a nonimmune biosensing technology.

A multiple mode integrated biosensor based on higher order Fano metamaterials.

A multiple mode integrated biosensor based on higher order Fano metamaterials (FRMMs) is proposed. The frequency shifts (Δf) of x-polarized quadrupolar (Qx), octupolar (Ox), hexadecapolar (Hx), y-polarized quadrupolar (Qy) and octupolar (Oy) Fano resonance modes are integrated to detect the concentration of lung cancer cells. In experiments, the concentrations of lung cancer cells can be distinguished by the shape and distribution of integrated graphics.