Sigh syndrome during the COVID-19 pandemic: Is it a signal of the mental health status of Chinese children and adolescents?

Background: Since the outbreak of the COVID-19 pandemic, Chinese children and adolescents have been greatly affected by the strict social isolation policies, which will undoubtedly cause psychological problems. We aimed to investigate the mental health status of Chinese children and adolescents, and provided some considerations of the contributing factors and the coping strategy.

Method: We investigated the disease composition ratio of sigh syndrome in the pediatric outpatient clinic in Chengdu after the outbreak of the COVID-19 pandemic and outbreak mitigation.

Development and evaluation of a Novel RT-PCR system for reliable and rapid SARS-CoV-2 screening of blood donations.

Background: The ongoing outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused great global concerns. In contrast to SARS, some SARS-CoV-2-infected people can be asymptomatic or have only mild nonspecific symptoms. Furthermore, there is evidence that SARS-CoV-2 may be infectious during an asymptomatic incubation period.

TAT-CC fusion protein depresses the oncogenicity of BCR-ABL in vitro and in vivo through interrupting its oligomerization.

Chronic myeloid leukemia (CML) is a clonal hematologic malignancy characterized by the BCR-ABL protein. BCR-ABL is a constitutively active tyrosine kinase and plays a critical role in the pathogenesis of CML. Imatinib mesylate, a selective tyrosine kinase inhibitor, is effective in CML, but drug resistance and relapse occur.

Purification of TAT-CC-HA protein under native condition, and its transduction analysis and biological effects on BCR-ABL positive cells.

BCR-ABL oncoprotein is the cause of chronic myeloid leukemia. The homologous oligomerization of BCR-ABL protein mediated by BCR coiled-coil (CC) domain plays an important role in ABL kinase activation. The HIV-1 TAT peptide has been used extensively for the introduction of proteins into cells.