Durable and biocompatible low adhesion wound dressing material based on interfacial behaviors for wound management.

Wound-dressing adhesion is a problem that has not been effectively addressed in the field of wound care for bleeding or burn wounds. Design of low adhesion wound dressing materials by leveraging interfacial behaviors has been an effective solution to this problem. However, previously reported superhydrophobic low adhesion materials either had durability or biocompatibility issue.

Miniaturized neural implants for localized and controllable drug delivery in the brain.

Drug delivery in the brain is challenging due to the existence of the blood brain barrier, which prevents most drugs from entering the target site in the brain. Compared to systematic drug administration, localized and site-specific drug delivery in a minimally invasive manner is effective for the treatment of brain disease. However, its implementation relies on advanced technologies and miniaturized implants/devices for controllable drug delivery.

A Miniaturized Ultrasonic Micro-Hole Perforator for Minimally Invasive Craniotomy.

Objective: Micro-hole perforation on skull is urgently desired for minimally invasive insertion of micro-tools in brain for diagnostic or treatment purpose. However, a micro drill bit would easily fracture, making it difficult to safely generate a micro-hole on the hard skull.

Methods: In this study, we present a method for ultrasonic vibration assisted micro-hole perforation on skull in a manner similar to subcutaneous injection on soft tissue.