Publications by authors named "Maoqiang Xu"
Objectives: The aim of this study was to explore the profile and function of CD4(+)CD25(+) regulatory T cells (Treg cells) in idiopathic thrombocytopenic purpura (ITP) patients.
Methods: Treg cell numbers were analyzed by flow cytometric analysis in peripheral blood mononuclear cells collected from healthy donors or patients with ITP. Quantification of cell proliferation was assayed by an enzyme-linked immunosorbent assay kit, based on the measurement of BrdU incorporation during DNA synthesis.
[Profiles of type 1 and type 2 T cells in chronic idiopathic thrombocytopenic purpura].
Zhonghua Yi Xue Za Zhi
March 2006
Article Synopsis
- The study aimed to examine the profiles of type 1 and type 2 T cells in patients with chronic idiopathic thrombocytopenic purpura (ITP), comparing their immune responses to healthy individuals.
- Blood samples were taken from 30 chronic ITP patients and 20 healthy controls, then analyzed for various T cell populations and cytokine levels using flow cytometry and real-time PCR methods.
- Results showed significantly higher Th1/Th2 and Tc1/Tc2 ratios in active ITP patients compared to those in remission and the control group, indicating a distinct immune profile associated with the disease's active phase.
The management of chronic and refractory idiopathic thrombocytopenic purpura (ITP) in children is controversial. We conducted a retrospective review of our single center experience in China between 1990 and 2003 with splenectomy for chronic ITP in children in order to determine the initial and long-term hematological response, morbidity, mortality, predictors of response to splenectomy and the therapy in children who failed splenectomy. Of 65 children analyzed, the overall immediate clinical response to splenectomy was 89.
View Article and Find Full Text PDFObjectives: The aim of this study was to explore the results of Chinese chronic idiopathic thrombocytopenic purpura (ITP) patients who underwent splenectomy (SE).
Subjects And Methods: Data of 149 chronic ITP patients were retrospectively analyzed. Relapse-free survival was estimated by Kaplan-Meier analysis.
Background And Objectives: Adult idiopathic thrombocytopenic purpura (ITP) is a chronic acquired organ-specific autoimmune hemorrhagic disease characterized by the production of antibodies against antigens on the membranes of platelet, resulting in enhanced Fc-mediated destruction of the platelets by macrophages in the reticuloendothelial system. Dysfunctional cellular immunity is considered important in the pathophysiology of ITP. The aim of this study was to explore the profile of type1 and type2 T cells in chronic ITP patients.
View Article and Find Full Text PDFObjective: To study the clinical characteristics and pathogenesis of hematidrosis.
Methods: Detailed clinical manifestations and natural history of a patient with hematidrosis were presented. A series of laboratory examinations were performed, and skin pathohistologic features and ultra microscopic structures were observed.