Publications by authors named "Maoko Goto"
To achieve the effective intracellular delivery of siRNA and silence specific genes, various types of conjugates between cell-penetrating peptides (CPPs; Transportan, Penetratin, Tat) and cationic peptides were developed. Uptake, intracellular localization, cytotoxicity, and biological activity of siRNA were significantly dependent on the kind of CPP used and the length of the cationic peptides in the conjugate. Transportan-based conjugates yielded both high internalization of siRNA and strong gene silencing activity, while Penetratin- and Tat-based conjugates did not.
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- Polymeric micelles using amphiphilic block copolymers have limitations in drug encapsulation, prompting researchers to create hybrid nanoparticles with improved solubilization features.
- The hybrid nanoparticles were made from a combination of PEG-PLA block copolymer and oleic acid calcium salt, showing enhanced ability to solubilize poorly water-soluble drugs compared to traditional polymeric micelles.
- These nanoparticles demonstrated high stability, effective drug entrapment, and protection against degradation, indicating their potential for improving the delivery of challenging therapeutic drugs.