Publications by authors named "Maojie Pan"
Advancing cancer therapy: new frontiers in targeting DNA damage response.
Front Pharmacol
September 2024
Article Synopsis
- * Targeted therapies, like PARP inhibitors, have shown promise in treating cancers with specific DDR defects, such as mutations in BRCA1 or BRCA2, by taking advantage of vulnerabilities through synthetic lethality.
- * Ongoing research aims to identify new DDR therapeutic targets and improve treatment strategies by optimizing therapies, understanding resistance mechanisms, and combining them with other treatment modalities.
Locally advanced thymic tumor usually invades adjacent great vessels, while the optimal treatment strategy for vessels resection and prosthetic replacement is still in controversial. We hereby present our series of patients undergoing autologous pericardial angioplasty for thymic malignancies. For invasive thymic tumors involving the superior vena cava (SVC), the replacement vessel was prepared by autologous pericardium and placed between the right atrium and distal left innominate vein stump to establish a SVC bypass.
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