Publications by authors named "Maohua Zhu"
Article Synopsis
- * The main issue is the ineffective targeting of drugs to tumors, which targeted drug delivery strategies aim to improve.
- * Liposomes are a promising type of nanocarrier that has shown significant progress in enhancing the effectiveness of cancer chemoimmunotherapy, and the review highlights recent advancements and future challenges in this area.
Article Synopsis
- * The hostile TME includes problems like low oxygen, acidity, and immunosuppressive factors, which negatively impact the function of immune cells that target tumors.
- * New advances in tumor metabolism-targeting nanomedicines are showing promise in improving immune responses by modifying various metabolic processes in tumors, and the article reviews this progress along with potential future challenges.
Article Synopsis
- Jujuboside B (JuB) is an active compound from traditional Chinese medicine that shows promise in preventing tumor blood vessel formation (angiogenesis), which is essential for solid tumor growth.
- In experiments, JuB effectively reduced the growth, movement, and tube formation of human endothelial cells related to blood vessels and inhibited angiogenesis in live chick embryos and in laboratory models.
- The study also found that JuB works by blocking key proteins involved in angiogenesis, suggesting its potential as a new treatment option for cancer that targets blood vessel formation.
Insulin-like growth factor 1 receptor (IGF-1R) expression and signaling play important roles in promotion of skin cancer progression. Identification of signaling pathways that regulate IGF-1R is crucial for understanding the pathogenesis and therapeutic treatment of skin cancer. Molecular, cellular and genetic approaches were used to investigate the function of PINCH-1 in regulation of IGF-1R expression and skin cell behavior.
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- Researchers developed a nanoparticle-based immune system activator (NISA) to enhance breast cancer immunotherapy by using mesoporous silica nanoparticles with mouse IgG3 Fc fragments.
- NISA is designed to activate the innate immune system components, such as macrophages and dendritic cells, by releasing Fc fragments in tumor environments through MMP-2 enzyme action.
- The study demonstrated that NISA effectively stimulates the immune response and exhibits strong antitumor effects in breast cancer models in mice.
Article Synopsis
- Nanosystems for cancer therapy need to deliver multiple drugs effectively to different locations in and around tumor cells, as current methods are limited by the tumor environment and drug release efficiency.
- A novel light-triggered delivery approach using liposomal formulations allows for rapid release of sunitinib for antiangiogenic therapy and immune modulation, significantly enhancing treatment effectiveness.
- The strategy improves drug uptake by tumor cells and leads to enhanced immune responses, showcasing its potential for multimodal cancer treatment targeting various tumor characteristics.
Article Synopsis
- Saikosaponin A (SSA), a component found in some plants, has been shown to have various health benefits, but its effect on angiogenesis (the formation of new blood vessels crucial for tumor growth) was previously unexplored.
- In experiments, SSA significantly reduced the proliferation, migration, and tube formation of cells related to blood vessel development, suggesting it effectively inhibits angiogenesis.
- The study found that SSA also inhibited tumor growth in breast and colorectal cancer models by blocking certain signaling pathways that promote angiogenesis, specifically by affecting the VEGFR2 protein.
We evaluated the alignment-to-orientation conversion (AOC) at the cesium D1 line to improve a nonlinear magneto-optical rotation (NMOR) optical atomic magnetometer's signal amplitude and bandwidth. For the 6 S F = 3 → 6 P F' = 4 transition, the AOC-related NMOR achieves a 1.7-fold enhancement in signal amplitude compared to the conventional NMOR, benefiting from narrow linewidth and ultraweak power broadening.
View Article and Find Full Text PDFUnlabelled: Small-sized trastuzumab-targeted micelles (T-MP) were engineered using a surfactant-stripping approach that yielded concentrated phthalocyanines with strong near infrared absorption. T-MP accumulated more in the lymph node (LN) metastases of orthotopic colorectal cancer compared to the micelles conjugated with control IgG. Following surgical resection of the primary tumor, minimally invasive photothermal treatment of the metastatic LN with T-MP, but not the control micelles, extended mouse survival.
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- Metal-phenolic networks (MPNs) are new surface modifiers that can be used in drug delivery systems.
- The researchers developed a core-satellite nanosystem (CS-NS) combining liposomes with a metal ion chelator and mesoporous silica nanoparticles loaded with doxorubicin, which are coated with an MPN.
- When exposed to near-infrared light, the CS-NS disassembles rapidly, enhancing drug delivery to tumors and improving survival rates in treated mice compared to controls.
Photodynamic therapy (PDT) of cancer is limited by tumor hypoxia. Platinum nanoparticles (nano-Pt) as a catalase-like nanoenzyme can enhance PDT through catalytic oxygen supply. However, the cytotoxic activity of nano-Pt is not comprehensively considered in the existing methods to exert their multifunctional antitumor effects.
View Article and Find Full Text PDFWe construct an active magnetic compensation device and propose an efficient magnetic compensation method that suppresses a wider range of frequencies and amplitudes of time-varying magnetic fields than conventional methods. This system can compensate for all frequencies in the bandwidth of the sensors used by analyzing and extracting the spectral characteristics of the ambient field. We compensate simultaneously for various types of interference in rotation and achieve a reduction of the 50-Hz power-frequency field noise by 36 dB.
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- Liposomal drug delivery for cancer therapy often faces challenges due to drugs leaking during circulation, which can reduce effectiveness.
- Researchers created a new method that uses a stiff nanobowl embedded in the liposomal water cavity to enhance the stability of doxorubicin (DOX) and prevent this leakage.
- This approach not only improves drug delivery to tumors but also boosts antitumor effects, making it a simpler and more effective solution compared to other methods that modify liposome surfaces.
To measure the residual magnetic field, which is a kind of static magnetic fields in the magnetic shields, is a tough task in the design of the cylindrical magnetic shields. Here, we demonstrate a method to measure static weak magnetic fields based on low-field nuclear magnetic resonance (NMR), where the static magnetic field's strength can be obtained by measuring nuclear spin precession's frequency. Atomic magnetometers can be adopted to sense the nuclear spin precession, and the nuclear spin can be adopted to measure the static magnetic field through this indirect method to obtain the static magnetic field's strength.
View Article and Find Full Text PDFWe report on a 795 nm atomic filter consisting of a stimulated Raman gain amplifier together with normal Faraday anomalous dispersion optical filtering (FADOF) at the rubidium D1 line. The filter is operated with a single transmission peak. The gain of the filter's transmission light signal is enhanced up to 85-fold compared to case operating without a stimulated Raman transition.
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