Publications by authors named "Maofeng Xie"
[Emodin alleviates pulmonary fibrosis through inactivation of TGF-β1/ADAMTS-1 signaling pathway in rats].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
October 2016
Objective To explore the role of transforming growth factor-β1 (TGF-β1)/a disintegrin-like and metalloproteinase with thrombospondin type 1 motif (ADAMTS-1) signaling pathway in emodin's anti-pulmonary fibrosis. Methods Sixty SD rats were randomly divided into 6 groups: normal control group, sham-operated group, model group, low-dose emodin intervention group (20 mg/kg), high-dose emodin intervention group (80 mg/kg) and prednisone group (5 mg/kg). Each group included 10 animals.
View Article and Find Full Text PDF[Emodin inhibits the proliferation, transdifferentiation and collagen synthesis of pulmonary fibroblasts].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
July 2016
Objective To explore the effect of emodin on the proliferation, differentiation into myofibroblasts and collagen synthesis of pulmonary fibroblasts and the underlying mechanisms. Methods Human pulmonary fibroblasts MRC-5 were cultured in vitro, then the cells were inoculated with dimethyl sulfoxide (DMSO) added with 0, 10, 20, 40, 80 and 160 μmol/L emodin for 24, 48 and 72 hours. Inhibitory rate of cell proliferation was analyzed by MTT assay.
View Article and Find Full Text PDFArticle Synopsis
- A recent study assessed the effects of suramin on lung adenocarcinoma in mice, finding it could inhibit tumor growth and metastasis.
- Suramin was compared with cisplatin in various treatment groups, showing significant tumor growth inhibition rates (34.9% for DDP, 23.8% for suramin, and 57.3% for the combination).
- Results indicated that suramin, alone or combined with cisplatin, reduced lung metastasis rates and lower protein expression levels of EGFR and P-selectin compared to control and cisplatin-only groups.