Publications by authors named "Maofang Zhao"
Purpose: Herein, an emerging drug delivery system was constructed based on zeolite imidazole backbone (ZIF-8) to improve antibacterial defects of nanosilver (AgNPs), such as easily precipitated and highly cytotoxic.
Methods: The homogeneous dispersion of AgNPs on ZIF-8 was confirmed by UV-Vis spectroscopy, FTIR spectroscopy, particle size analysis, zeta potential analysis, and SEM. The appropriate AgNPs loading ratio on ZIF-8 was screened through the cell and antibacterial experiments based on biosafety and antibacterial performance.
Purpose: Clear cell renal cell carcinomas (ccRCCs) are the most common form of renal cancer in the world. The loss of extracellular matrix (ECM) stimulates cell apoptosis, known as anoikis. A resistance to anoikis in cancer cells is believed to contribute to tumor malignancy, particularly metastasis; however, the potential influence of anoikis on the prognosis of ccRCC patients is not fully understood.
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- Obesity is a global health crisis linked to serious diseases like hypertension, diabetes, and heart disease, largely driven by high-fat diets (HFD).
- HFD reduces hydrogen sulfide (HS) and its enzyme cystathionine β-synthase (CBS) in the brain, leading to inflammation through mTOR and NF-κB pathways, which damages hypothalamic neurons and contributes to weight gain.
- Restoring HS levels or inhibiting mTOR/NF-κB signaling can reduce inflammation and weight gain, suggesting a potential therapeutic approach to preventing obesity.
Noise is a kind of sound that causes agitation and harms human health. Studies have shown that noise can lead to neuroinflammation, damage to synaptic plasticity and altered levels of neurotransmitters that may result in depression. The present study demonstrated that luteolin exerted antidepressant-like effects by improving neuroinflammation in a mouse model of noise-induced depression.
View Article and Find Full Text PDFHS is the third gas transmitter affecting the growth, reproduction and survival of cancer cells. However, the HS anticancer and antitumor mechanism still needs to be further studied. Here, FHS-1 was synthesized utilizing excited-state intramolecular proton transfer to detect HS in MCF-7 cells, and investigated the effects of varying concentrations NaHS on apoptosis.
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