Publications by authors named "Maocheng Yu"
Adv Sci (Weinh)
August 2024
Article Synopsis
- Multidrug resistance (MDR) in cancer hinders chemotherapy effectiveness, but combining chemotherapeutics with siRNA targeting efflux pumps shows potential in overcoming this challenge.
- Researchers developed tetrahedral DNA-RNA nanocages (TDRN) to co-deliver the cancer drug doxorubicin and P-glycoprotein (P-gp) siRNA, offering dynamic control over treatment delivery through a stable nanostructure.
- The TDRN system demonstrates enhanced stability and biocompatibility, enabling effective delivery and synergistic treatment of cancer in both lab settings and animal models, marking a promising strategy for addressing MDR tumors.
