Molecular Profiling Reveals Common and Specific Development Processes in Different Types of Gynecologic Cancers.

Background: Gynecologic cancers have become a major threat to women's health. The molecular biology of gynecologic cancers is not as well understood as that of breast cancer, and precision targeting is still new. Although viewed collectively as a group of cancers within the female reproductive system, they are more often studied separately.

Memetic Differential Evolution with an Improved Contraction Criterion.

Memetic algorithms with an appropriate trade-off between the exploration and exploitation can obtain very good results in continuous optimization. In this paper, we present an improved memetic differential evolution algorithm for solving global optimization problems. The proposed approach, called memetic DE (MDE), hybridizes differential evolution (DE) with a local search (LS) operator and periodic reinitialization to balance the exploration and exploitation.

Compact differences of weighted composition operators on the weighted Bergman spaces.

In this paper, we consider the compact differences of weighted composition operators on the standard weighted Bergman spaces. Some necessary and sufficient conditions for the differences of weighted composition operators to be compact are given, which extends Moorhouse's results in (J. Funct.

Constructing Pairing-Friendly Elliptic Curves under Embedding Degree 1 for Securing Critical Infrastructures.

Information confidentiality is an essential requirement for cyber security in critical infrastructure. Identity-based cryptography, an increasingly popular branch of cryptography, is widely used to protect the information confidentiality in the critical infrastructure sector due to the ability to directly compute the user's public key based on the user's identity. However, computational requirements complicate the practical application of Identity-based cryptography.

Biological characteristics and construction of stable ALDH-1 knock-down Hela cell lines.

Objectives: To explore the relationship between aldehye dehydrogenase-1 (ALDH-1) and biological characteristics of the stable ALDH-1 knock-down Hela cell lines.

Materials And Methods: Transfected Hela cells with lentiviral vector were utilized and puromycin was used to screen and achieve the stable cell lines. The interference efficiency was calculated by performing qRT-PCR to detect the expression of ALDH-1 of three groups including the interfering group, the negative control (NC) group, and the normal Hela group.

APOBEC3A possesses anticancer and antiviral effects by differential inhibition of HPV E6 and E7 expression on cervical cancer.

Cervical cancer is the second most common cancer among women worldwide and is the leading cause of deaths in developing countries. Persistent infections with a subset of HPVs, called "high-risk HPVs", including HPV16 and HPV18, are the primary cause of cervical cancer. The apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC) family of proteins is a group of cellular enzymes that catalyze the deamination of cytidine (C) to uracil (U) in single-stranded DNA/RNA, and functions as antiviral factors in the innate immune system of the host.

A novel multiobjective evolutionary algorithm based on regression analysis.

As is known, the Pareto set of a continuous multiobjective optimization problem with m objective functions is a piecewise continuous (m - 1)-dimensional manifold in the decision space under some mild conditions. However, how to utilize the regularity to design multiobjective optimization algorithms has become the research focus. In this paper, based on this regularity, a model-based multiobjective evolutionary algorithm with regression analysis (MMEA-RA) is put forward to solve continuous multiobjective optimization problems with variable linkages.