Evaluation of the efficacy and surgical-related safety of neoadjuvant immunochemotherapy in advanced resectable none small cell lung cancer (NSCLC).

Background: The emergence of immune checkpoint inhibitors (ICIs) has brought about a paradigm shift in the treatment landscape of non-small cell lung cancer (NSCLC). Despite the promising long-term survival outcomes and optimization of pathological complete response (cPR) demonstrated by various studies such as Impower010 and Checkmate-816, the effectiveness of neoadjuvant immunotherapy in advanced resectable NSCLC remains a subject of debate. Although previous research has explored the connection between the efficacy of neoadjuvant therapy and surgical-related safety, limited studies have specifically investigated the surgical-related safety of neoadjuvant immunotherapy.

[Effects of biochar addition on soil moisture infiltration process of the yellow soil in Karst area].

To investigate the effects of biochar addition on soil moisture infiltration characteristics of sloping farmland in Karst area, we used soil column simulation to study the variation characteristics of cumulative infiltration volume, infiltration rate, and wetting peak process under the different biochar addition amount (0, 1% and 2%) and different particle sizes (<0.25, 0.25-1 and >1 mm), and simulated the infiltration process in yellow soil on slope farmland.

Ferroelectric Perovskite Oxide@TiO Nanorod Heterostructures: Preparation, Characterization, and Application as a Platform for Photoelectrochemical Bioanalysis.

This work reports the first synthesis and characterization of a ferroelectric perovskite oxide-based heterostructure as well as its application for photoelectrochemical (PEC) bioanalytical purposes. Specifically, exemplified by [KNbO][BaNiNbO] (KBNNO), the ferroelectric perovskite oxides were prepared by solid-state synthesis, while the TiO nanorod (NR) arrays were obtained via a hydrothermal method. Using the technique of pulsed laser deposition (PLD), KBNNO were then deposited on TiO NRs to form KBNNO@TiO NR heterostructures.

Direct electrochemical sensor for label-free DNA detection based on zero current potentiometry.

A direct electrochemical DNA biosensor based on zero current potentiometry was fabricated by immobilization of ssDNA onto gold nanoparticles (AuNPs) coated pencil graphite electrode (PGE). One ssDNA/AuNPs/PGE was connected in series between clips of working and counter electrodes of a potentiostat, and then immersed into the solution together with a reference electrode, establishing a novel DNA biosensor for specific DNA detection. The variation of zero current potential difference (ΔE(zcp)) before and after hybridization of the self-assembled probe DNA with the target DNA was used as a signal to characterize and quantify the target DNA sequence.

A novel lable-free electrochemical immunosensor for carcinoembryonic antigen based on gold nanoparticles-thionine-reduced graphene oxide nanocomposite film modified glassy carbon electrode.

In this paper, gold nanoparticle-thionine-reduced graphene oxide (GNP-THi-GR) nanocomposites were prepared to design a label-free immunosensor for the sensitive detection of carcinoembryonic antigen (CEA). The nanocomposites with good biocompatibility, excellent redox electrochemical activity and large surface area were coated onto the glassy carbon electrode (GCE) surface and then CEA antibody (anti-CEA) was immobilized on the electrode to construct the immunosensor. The morphologies and electrochemistry of the formed nanocomposites were investigated by using scanning electron microscopy (SEM), ultraviolet-visible (UV-vis) spectrometry, electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV).

On the origin of the relative stability of Wells-Dawson isomers: a DFT study of α-, β-, γ-, α*-, β*-, and γ*-[(PO4)2W18O54](6-) anions.

Density functional theory calculations have been carried out to investigate α-, β-, γ-, α*-, β*-, and γ*-[(PO(4))(2)W(18)O(54)](6-) Wells-Dawson isomers, which exhibited stability in the order of α > β > γ > γ* > β* > α*, reproduced the experimental observations (α > β > γ), and confirmed the hypothesis of Contant and Thouvenot (γ* > β* > α*). Energy decomposition analysis reveals that both the spatial arrangement of the host W(18)O(54) cage (eclipsed or staggered) and its structural distortion induced by the encapsulated guest anions are two dominant factors in control of the stability order, while the influences of host-guest interaction and distortion of the guest anions are very small. A building block decomposition approach is designed and provides an effective means to clarify the detailed relationship between the local distortion and energy.

On the origin of the inverted stability order of the reverse-Keggin [(MnO4)(CH3)12Sb12O24]6-: a DFT study of alpha, beta, gamma, delta, and epsilon isomers.

Density functional theory calculations have been carried out to investigate the alpha, beta, gamma, delta, and epsilon isomers of [(MnO(4))Me(12)Sb(12)O(24)](6-) (Me = CH(3)) anions, which are simplified Baker-Figgis models of Keggin-type antimonate complexes in experiments. It is found that the stability order of the five isomers (alpha < beta < gamma < delta < epsilon) perfectly reverses to the well-known trend of the classical Keggin [PW(12)O(40)](3-) anions (alpha > beta > gamma > delta > epsilon), despite their significant similarities in frameworks. On the basis of the building block decomposition method, the stabilizing effect of the edge-sharing [Sb(2)(mu-O)(2)Me(2)] fragment inside gamma, delta, and epsilon structures is confirmed and found to originate from its two energy-favorable components rather than itself as an indivisible unit.

[Determination of the cysteine residues in the surface-confined biomolecules by using electrochemical desorption and fluorescence detection].

To develop a method for the detection of surface-confined peptides containing cysteine residues or oligodeoxynucleotides (ODNs) whose 3' ends modified with thiol groups, and a thiol-specific fluorescent cross-linker, N-(9-acridinyl) maleimide (NAM) was used. The peptides studied herein include both the oxidized and reduced forms of glutathione, and a hexapeptide (FT). Peptides are first attached onto the activated 11-mercaptoundecanoic acid (MUA)-terminated alkanethiol self-assembled monolayers (SAMs) and then derivatized with NAM.

catena-Poly[[[diaqua-iron(II)]-μ-pyridine-2,5-dicarboxyl-ato-[tetra-aqua-iron(II)]-μ-pyridine-2,5-dicarboxyl-ato] tetra-hydrate].

In the crystal structure of the title compound, {[Fe(2)(C(7)H(3)NO(4))(2)(H(2)O)(6)]·4H(2)O}(n), there are two types of coordination for the Fe(II) atoms. One Fe(II) atom is in a distorted octa-hedral N(2)O(4) environment, with two chelating rings from the pyridine-dicarboxyl-ate ligands and two O atoms from the water mol-ecules, while the other is in a distorted octa-hedral O(6) environment with two O atoms from the pyridine-dicarboxyl-ate ligands and four O atoms from the water mol-ecules. Both Fe(II) atoms lie on crystallographic centers of symmetry.

[Polarographic behavior and determination of glimepiride].

Aim: To establish a polarographic method of parallel catalytic hydrogen wave for determination of glimepiride.

Methods: The catalytic wave of glimepiride in the presence of K2S2O8 was used to improve the analytical sensitivity. The rapid determination of glimepiride was done by linear single sweep polarography.

[A novel catalysis kinetics fluorimetry system for the determination of eliminating ratio of Chinese traditional medicine for *OH].

Benzoic acid with weak fluorescence may react on *OH, and then products with intense fluorescence are made. Extractives of Chinese traditional medicine may eliminate *OH in solution, and reduce the amounts of the products. Then, the increased level of fluorescence of the products in solution will be lowered.

[Polarographic catalytic wave of clarithromycin and its applications].

Aim: To develop a new method for the determination of clarithromycin.

Methods: The catalytic wave of clarithromycin in the presence of K2S2O8 was used for improving the analytical sensitivity. The rapid determination of clarithromycin has been carried out by linear single sweep polarography.