[Application of intraoperative ultrasound combined with neuronavigation for resection of intracranial cavernous malformations in minimally invasive neurosurgery].

Objectives: To analyze the reliability and clinical value of intraoperative ultrasound combined with neuronavigation for resection of intracranial cavernous malformations.

Methods: From January 2007 to December 2009, 40 cases of intracranial cavernous malformations were operated under the application of intraoperative ultrasound combined with neuronavigation. There were 18 male and 22 female, aged 18 to 58 years, with a mean age of 34.

[Microsurgical treatment of adult craniopharyngiomas in 156 cases].

Objective: To explore the clinical features, surgical approaches and outcomes of craniopharyngioma in adults.

Methods: A total of 156 cases of adult craniopharyngioma underwent microsurgery at our hospital were retrospectively reviewed and classified into four types according to the location of tumor relative to sellar diaphragm and the third ventricle. They were divided into four groups: intrasellar type (n = 6), suprasellar & extraventricular type (n = 59), intraventricular type (n = 63) and mixed type (n = 28).

[Value of intra-operative ultrasound in detecting the boundaries of intra cranial gliomas].

Objective: To evaluate the application of intra-operative ultrasound (IOUS) in detecting the boundaries of intracranial gliomas.

Methods: One hundred and five consecutive patients with supra-tentorial glioma were included, male: 42 cases, female: 46 cases, age ranged from 15 - 67 years (mean 41 yrs), intra-operative ultrasound B was used to detect tumour boundaries before and after resection in 88 cases, tissues with suspicious echo was taken for verification by histological examination. And repeated MRI scan was received within 3 day after operation to judge the resection extent.

[Application of individually designed trans-fissure approach in brain surgery: analysis of 90 cases].

Objective: To explore the feasibility and value of trans-fissure approaches in brain surgery through individually designed craniotomy.

Methods: Ninety patients with intracranial space-occupying lesions, 47 males and 58 females, aged (43 +/- 14) (1 - 68), were treated by individualized trans-fissure approach surgeries. Linear scalp incision or "horseshoe shape" scalp incision were designed to perform the operation, with a bone flap 3 - 4 cm in diameter.

Intraoperative contrast-enhanced ultrasound for brain tumors.

Objective: The purpose of this study was to investigate the feasibility and value of the intraoperative contrast-enhanced ultrasound (CEUS) in resection for brain tumors.

Materials And Methods: Intraoperative CEUS was performed in 29 patients with brain tumors pre-resection, in whom 9 (of 29) patients underwent second intraoperative CEUS for assessing remained tumor tissue after initial resection. Gray-scale and color-flow images of the brain tumors on both conventional and CEUS were analyzed and compared with the results of surgical pathology.

Treatment of alternated water-electrolyte balance and endocrine status after removal of craniopharyngioma in adults.

Background: Water-electrolyte disturbance and endocrine alterations are common complications of adult patients with craniopharygioma in the postoperative period and may affect their recovery and prognosis. Some of these complications even lead to death. Appropriate remedy based upon the status of water-electrolyte balance and the endocrine system is essential to good therapeutic results of adult patients with craniopharyngioma.

[Ultrasound-guided minimally invasive neurosurgery in treatment of cranial tumors: clinical study].

Objective: To explore the applicability of ultrasound-guided minimally invasive neurosurgery in treatment of intracranial tumors.

Methods: Thirty five patients with intracranial tumors diagnosed with preoperative CT and MRI underwent craniotomy. Intraoperative real-time monitoring ultrasound was conducted to detect the location, size and depth of the cerebral masses so as to determine the appropriate approach.

[Application of diffusion tensor imaging fractography in minimally invasive surgery of brain tumors].

Objective: To investigate the effects and prospect of application of diffusion tensor imaging (DTI) fractography in minimally invasive surgery of brain tumors.

Methods: DTI fractography was performed in 52 patients with malignant brain tumors. Based on the DTI fractography results, 34 of the 52 patients underwent operation under neuro-navigation, and 18 of the 52 patients underwent operation routine minimally invasive craniotomy and tumor resection without neuro-navigation.

Clinical and pathological characteristics of septum pellucidum tumor and choice of surgical approaches for its resection.

Background: Tumor involving the septum pellucidum is uncommon. Surgery as the main therapeutic procedure for this lesion is a challenge to neurosurgeons. We analyzed the clinical characteristics and pathological features of septum pellucidum tumor in 41 patients and compared the curative effects of frontal transcortical, trans-sulcal and interhemispheric transcallosal approaches.

[Photodynamic diagnosis and fluorescence-guided resection of malignant gliomas: a report of 15 cases].

Objective: To study the usefulness of the intraoperative photodynamic diagnosis (PDD) and fluorescence-guided resection of malignant gliomas.

Methods: Fifteen consecutive patients with malignant gliomas received doses of hematoporphyrin derivative (HPD, 2 mg/kg body weight) 48 hours before induction of anesthesia. After the tumors recognized by bare eyes they were removed routinely.

The supraorbital keyhole approach with eyebrow incisions for treating lesions in the anterior fossa and sellar region.

Background: Keyhole surgery has developed since the 1990s as a less invasive therapeutic strategy for intracranial lesions, initially for the treatment of intracranial aneurysms. The purpose of this study was to describe and evaluate the results of surgical treatment of lesions in the anterior fossa and sellar region via a supraorbital keyhole approach using eyebrow incisions.

Methods: Between April 1994 and July 2003, 54 patients with lesions in the anterior fossa and sellar region were operated on via the supraorbital keyhole approach.