Publications by authors named "Mao-Yuan Mu"
Article Synopsis
- DTL, a protein involved in the CRL4A complex, is crucial for maintaining genome stability and has been linked to various cancers, but its role in hepatocellular carcinoma (HCC) needs more exploration.
- Research involving a clinical cohort and RNA-sequencing indicates that DTL is associated with patient outcomes in HCC and could be a useful prognostic marker.
- DTL enhances HCC cell growth, metastasis, and drug resistance, and is activated by HIF-1α in low-oxygen conditions, suggesting it might be a potential target for treatment and diagnosis in HCC.
Background: Uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) plays a crucial role in metabolizing and detoxifying endogenous and exogenous substances. However, its contribution to the progression of liver damage remains unclear.
Aim: To determine the role and mechanism of UGT1A1 in liver damage progression.
Aim: To investigate the protective effect of prostaglandin E1 (PGE1) against endoplasmic reticulum (ER) stress-induced hepatocyte apoptosis, and to explore its underlying mechanisms.
Methods: Thapsigargin (TG) was used to induce ER stress in the human hepatic cell line L02 and hepatocarcinoma-derived cell line HepG2. To evaluate the effects of PGE1 on TG-induced apoptosis, PGE1 was used an hour prior to TG treatment.