Publications by authors named "Mao Dan"

Objectives: Interleukin-8 (IL-8), a proinflammatory factor in human tissues, plays an important role in inflammation. Type IV collagen, a key component of the basement membrane, interacts with integrins, which are primary receptors in the extracellular matrix (ECM). Integrins are essential for the regulation of various cellular behaviors and signal transduction pathways.

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Patients with advanced-stage cancers often suffer from severe pain caused by bone metastasis and destruction, for which effective treatment options are limited. Liu-Shen-Wan (LSW) is a widely recognized herbal formula utilized for pain relief. This study aims to elucidate the effects of LSW on bone cancer pain (BCP).

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Few layers of graphene at small twist angles have emerged as a fascinating platform for studying the problem of strong interactions in regimes with a nearly quenched single-particle kinetic energy and nontrivial band topology. Starting from the strong-coupling limit of twisted bilayer graphene with a vanishing single-electron bandwidth and interlayer tunneling between the same sublattice sites, we present an exact analytical theory of the Coulomb interaction-induced low-energy optical spectral weight at all integer fillings. In this limit, while the interaction-induced single-particle dispersion is finite, the optical spectral weight vanishes identically at integer fillings.

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Camellia oil is valuable as an edible oil and serves as a base material for a range of high-value products. plants of significant economic importance, such as and , have been classified into sect. and sect.

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China has over 100 million people living with type 2 diabetes mellitus (T2DM). Interventions framed around pre-existing personal beliefs in the supernatural may improve T2DM self-management, but such interventions are lacking in China. This pilot randomized controlled trial (RCT) assessed the feasibility of a full-scale RCT to evaluate the efficacy of a supernatural beliefs-based intervention on T2DM management self-efficacy in China.

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Chiral multi-resonance thermally activated delayed fluorescence (CP-MR-TADF) materials hold promise for circularly polarized organic light-emitting diodes (CP-OLEDs) and 3D displays. Herein, we present two pairs of tetraborated intrinsically axial CP-MR-TADF materials, R/S-BDBF-BOH and R/S-BDBT-BOH, with conjugation-extended bidibenzo[b,d]furan and bidibenzo[b,d]thiophene as chiral sources, which effectively participate in the distribution of the frontier molecular orbitals. Due to the heavy-atom effect, sulfur atoms are introduced to accelerate the reverse intersystem crossing process and increase the efficiency of molecules.

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Article Synopsis
  • Global warming is leading to increased scrutiny of environmental issues, particularly in materials like crystalline silicon used in photovoltaics and semiconductors, which produces significant silicon waste during cutting.
  • The article assesses the environmental impacts of hydrogen production using diamond-wire sawing silicon waste (DSSW) compared to alkaline water electrolysis (AEL), with findings showing that the hydrogen production stage in the DSSW method has substantial environmental impacts.
  • While the DACH route (using DSSW) has a higher environmental impact than the AEL route, it's primarily due to raw material use, whereas AEL’s impact stems from electricity consumption; using renewable energy for AEL could greatly lessen its environmental effects.
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Article Synopsis
  • - This study explores how the NOD1 pathway, triggered by the recognition of a bacterial component called iE-DAP, impacts the production of IL-8 in oral epithelial cells, particularly in the context of periodontal disease.
  • - Researchers found that iE-DAP activates signaling pathways, specifically p38 MAPK and ERK1/2, leading to increased IL-8 production which helps recruit immune cells to fight bacterial infections in gum tissues.
  • - The findings suggest that while iE-DAP enhances pro-inflammatory responses in gingival epithelial cells, the JNK signaling pathway does not contribute to IL-8 production, indicating a more targeted immune response mechanism.
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Objective: To investigate the safety and mid-term outcomes of hydrodissection-assisted microwave ablation (MWA) of hepatocellular carcinoma (HCC) in various difficult locations.

Methods: A total of 131 HCC patients who underwent ultrasound-guided MWA from March 2017 to March 2019 were included. Following ultrasound examination, patients with tumors at difficult locations were treated with hydrodissection-assisted MWA (hydrodissection group), while those with tumors at conventional locations received MWA (control group).

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Fractionalization without time-reversal symmetry breaking is a long-sought-after goal in the study of correlated phenomena. The earlier proposal of correlated insulating states at n±1/3 filling in twisted bilayer graphene and recent experimental observations of insulating states at those fillings strongly suggest that moiré graphene systems provide a new platform to realize time-reversal symmetric fractionalized states. However, the nature of fractional excitations and the effect of quantum fluctuation on the fractional correlated insulating states are unknown.

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Tumor necrosis factor-alpha (TNF-α) is a major inflammatory cytokine that induces interleukin (IL)-8 production. Although some studies have reported the involvement of the p38 MAPK signaling pathway in TNF-α-induced IL-8 production, its specific regulatory mechanisms in gingival epithelial cells (GECs) are still poorly understood. In the present study, Ca9-22 cells were used as representative GECs to investigate the effect of p38 signaling on TNF-α-induced IL-8 production.

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Superconductivity is a macroscopic manifestation of a quantum phenomenon where pairs of electrons delocalize and develop phase coherence over a long distance. A long-standing quest has been to address the underlying microscopic mechanisms that fundamentally limit the superconducting transition temperature, . A platform which serves as an ideal playground for realizing "high"-temperature superconductors are materials where the electrons' kinetic energy is quenched and interactions provide the only energy scale in the problem.

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Background: Gut microbiota characteristics in patients with diffuse large B-cell lymphoma (DLBCL) are reportedly different when compared with the healthy population and it remains unclear if the gut microbiota affects host immunity and clinical disease features. This research investigated the gut microbiota in patients with untreated DLBCL and analyzed its correlation with patient clinical characteristics, humoral, and cell immune status.

Methods: Thirty-five patients with untreated DLBCL and 20 healthy controls (HCs) were recruited to this study and microbiota differences in stool samples were analyzed by 16S rDNA sequencing.

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Radiotherapy is a promising treatment option for lung cancer, but patients' responses vary. The purpose of the study was to investigate the potential of radiomics and clinical signature for predicting the radiotherapy sensitivity and overall survival of inoperable stage III and IV non-small-cell lung cancer (NSCLC) patients. This retrospective study collected 104 inoperable stage III and IV NSCLC patients at the Yunnan Cancer Hospital from October 2016 to September 2020.

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Article Synopsis
  • The study investigates the effect of Yanghe decoction, a Chinese herbal remedy, on pain relief in rats with bone metastasis from breast cancer induced by MCF-7 cells.
  • The research methods include behavioral assessments for pain response, as well as various biochemical analyses to evaluate changes in TRPA1 expression and inflammatory markers.
  • The findings suggest that Yanghe decoction relieves bone pain and inflammation by modulating TRPA1 signaling and reducing cytokine production, indicating potential therapeutic roles in managing breast cancer-related bone pain.
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Herein, we have employed linear-response time dependent density functional theory (LR-TDDFT)-based nonadiabatic dynamics simulations to investigate the ultrafast charge transfer in a nonfullerene all-small-molecule donor-acceptor (D-A) system formed by a porphyrin small-molecule donor ZnP and a recently developed nonfullerene small-molecule acceptor 6TIC, during which the optimally tuned range-separated hybrid (OT-RSH) functional was adopted. In combination with static electronic structure calculations, several important conclusions were drawn. Firstly, the ZnP and 6TIC are more likely combined together non-covalently in parallel rather than in perpendicular to form ZnP-6TIC due to the much larger adsorption energies, -44.

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Objective: To analyze and sum up clinical application regularities of Chengshan (BL57) acupoint in ancient Chinese literature.

Methods: The book (, 5 edition) containing 1 156 ancient medical books was used as the retrieved literature source. The key retrieval words used were BL57 acupoint related indications, prescriptions, treatment methods and taboos, followed by sorting out relevant articles and establishing a database.

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Objective: To investigate the clinical efficacy of different acupuncture points in the treatment of ankylosing spondylitis with supervised moxibustion.

Methods: Retrospective analysis of 61 AS patients (diagnosed as ankylosing spondylitis of kidney-yang deficiency type by Chinese medicine) admitted to our hospital from January 2020 to February 2021, randomly divided into 30 cases in the experimental group (Du moxibustion + basic western medicine treatment) and 31 cases in the control group (basic western medicine treatment alone). The changes in quantitative scores of the main symptoms and major signs (thoracic mobility, occipital-wall distance, finger-ground distance, and laboratory index (ESR)) were analyzed before and after treatment.

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Neuroglobin is an oxygen-binding heme protein expressed predominantly in the brain. Despite many years of research, the exact distribution and expression of neuroglobin in the neocortical development and under mild hypoxia stress still remain unclear. Therefore, we aim to explore the expression of neuroglobin during neocortex expansion and under mild hypoxia stress .

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In van der Waals (vdW) materials, strong coupling between different degrees of freedom can hybridize elementary excitations into bound states with mixed character. Correctly identifying the nature and composition of these bound states is key to understanding their ground state properties and excitation spectra. Here, we use ultrafast spectroscopy to reveal bound states of d-orbitals and phonons in 2D vdW antiferromagnet NiPS.

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The aim of this study was to investigate the effects of surface reaction-type pre-reacted glass-ionomer (S-PRG) filler eluate on Matrix metalloproteinase (MMP)-1 and MMP-3 secretion by human gingival fibroblasts (HGF). The S-PRG filler eluate contains 6 ions (F, Na, Al, B, Sr and Si) released from the S-PRG filler. The S-PRG filler eluate stimulation induced a slight secretion of MMP-1 and MMP-3 by HGF.

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Collective excitations of bound electron-hole pairs-known as excitons-are ubiquitous in condensed matter, emerging in systems as diverse as band semiconductors, molecular crystals, and proteins. Recently, their existence in strongly correlated electron materials has attracted increasing interest due to the excitons' unique coupling to spin and orbital degrees of freedom. The non-equilibrium driving of such dressed quasiparticles offers a promising platform for realizing unconventional many-body phenomena and phases beyond thermodynamic equilibrium.

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Chondroitin polymerizing factor (CHPF) plays an important role in the development of certain malignant tumors. However, the role of CHPF in breast carcinoma (BRCA) and its underlying mechanism are still not fully elucidated. Expression profiles for CHPF in BRCA tissues were retrieved from The Cancer Genome Atlas database and used for prognostic analysis.

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