Publications by authors named "Manyin Wu"
Article Synopsis
- roX RNAs are essential for male development in Drosophila, and their absence leads to male lethality during late larval stages.
- They are known for their role in balancing X-linked gene expression but have shown to also target autosomal genes, which had not been extensively studied before.
- The research highlights that roX RNAs function as both activators of X-linked genes and repressors of autosomal genes through their interactions with specific protein complexes, revealing a complex role in gene regulation.
Article Synopsis
- M1 macrophages help protect against infections but can also contribute to diseases related to metabolism and inflammation, driven by the E3 ubiquitin ligase MDM2.
- MDM2 enhances the production of inflammatory molecules like IL-1β, MCP-1, and nitric oxide (NO) in M1 macrophages by degrading SPSB2, which stabilizes iNOS and activates the HIF-1α pathway.
- Deleting MDM2 in immune cells reduces inflammation and damage in obesity and sepsis models, but may lead to higher mortality and bacterial infections when M1 macrophage responses are suppressed.
The Role of Long Non-coding RNAs in Human Imprinting Disorders: Prospective Therapeutic Targets.
Front Cell Dev Biol
October 2021
Article Synopsis
- Genomic imprinting involves genes that are expressed differently depending on whether they are inherited from the mother or father, with long non-coding RNAs playing a crucial role in this process.
- Imprinted long non-coding RNAs help regulate the expression of other genes in their cluster, and abnormal expression of these RNAs can lead to issues like bi-allelic expression or silencing of nearby genes.
- Understanding how long non-coding RNAs function is important for creating targeted therapies for imprinting disorders such as Prader-Willi syndrome and Angelman syndrome.