Preliminary Study of a Novel Ga-Labeled Probe Targeting Neuropilin-1 for Tumor Diagnosis.

Neuropilin-1 (NRP-1), a transmembrane protein related to tumor progression and invasion, presents potential as a prospective biomarker for tumor diagnosis and therapy. Positron emission tomography (PET) is acknowledged as an ideal modality for accurately monitoring NRP-1 expression due to its superior sensitivity and resolution. In this study, a novel peptide-based PET imaging probe, [Ga]Ga-DOTA-NEP, was successfully developed for specifically visualizing NRP-1 expression in tumors.