Effect of non-recommended doses versus recommended doses of direct oral anticoagulants in atrial fibrillation patients: A meta-analysis.

Background: Several observational studies have shown that the inappropriate dosing use of direct oral anticoagulants (DOACs) in atrial fibrillation (AF) that does not conform to recommendations is becoming a widespread phenomenon. Therefore, we performed a meta-analysis and systematic review to assess the effect of non-recommended doses versus recommended doses of DOACs on the effectiveness and safety outcomes among AF patients.

Methods: The PubMed and Ovid databases were systematically searched to identify the relevant studies until December 2020.

The role of non-vitamin K antagonist oral anticoagulants in Asian patients with atrial fibrillation: A PRISMA-compliant article.

Background: Given the huge burden of atrial fibrillation (AF) and AF-related stroke in Asia, stroke prevention represents an urgent issue in this region. We herein performed a network meta-analysis to examine the role of non-vitamin K antagonist oral anticoagulants (NOACs) in Asian patients with AF.

Methods: A systematic search of the publications was conducted in PubMed and Embase databases for eligible studies until July 2019.

Procyanidin B2 protects against diet-induced obesity and non-alcoholic fatty liver disease the modulation of the gut microbiota in rabbits.

Background: Procyanidins have beneficial effects on metabolic syndrome and antimicrobial activity, but the mechanisms underlying these effects are unclear.

Aim: To investigate the effects of procyanidin B2 (PB2) on non-alcoholic fatty liver disease and to explore the possible mechanism.

Methods: Thirty male New Zealand white rabbits were randomized into three groups.

No-tillage and fertilization management on crop yields and nitrate leaching in North China Plain.

A field experiment was performed from 2003 to 2008 to evaluate the effects of tillage system and nitrogen management regimes on crop yields and nitrate leaching from the fluvo-aquic soil with a winter wheat (Triticum aestivum L.)-maize (Zea mays L.) double-cropping system.

Competitive sorption behavior of copper(II) and herbicide propisochlor on humic acids.

The competitive sorption behavior of Cu2+ and propisochlor on humic acids (HA) was investigated using a batch method. The sorption equilibrium time of propisochlor on HA was 12 h when its initial concentration was 4 or 10 mg L(-1). The results showed that the Langmuir model can best describe the sorption behavior of propisochlor on HA.