Identification of key pathways and genes in nonalcoholic fatty liver disease using bioinformatics analysis.

Introduction: Nonalcoholic fatty liver disease (NAFLD) is one of the most common types of liver disease in the world. However, the molecular mechanisms regulating the development of NAFLD have remained unclear.

Material And Methods: In the present study, we analyzed two public datasets (GSE48452 and GSE89632) to identify differentially expressed mRNAs in the progression of NAFLD.

Correlation between serum 25-OH vitamin D expression and non-alcoholic fatty liver disease.

This study investigated changes in the level of serum 25-OH vitamin D [25-hydroxyvitamin D, 25(OH)D] in patients with non-alcoholic fatty liver disease (NAFLD) and the correlation between the severity of NAFLD and 25(OH)D. A retrospective analysis was performed on 385 NAFLD patients (NAFLD group) admitted to the Zhongshan Hospital Affiliated to Xiamen University from January 2015 to December 2017 and 347 healthy people with physical examination (control group). The height and weight of all subjects were measured, and BMI was calculated.

[The changes in protein content and procoagulantory activity of platelet-associated tissue factor in thrombotic diseases].

Objective: To explore the change in the protein content and procoagulant activity of platelet-associated tissue factor (TF) in thrombotic diseases.

Methods: Platelets were isolated with Sepharose 2B gel column. ELISA was employed to detect the TF protein content in the lysates of washed platelets, procoagulant activity of platelet-associated TF was measured with one stage clotting time assay.