Publications by authors named "Manvi Arora"
Genetic etiological spectrum of sperm morphological abnormalities.
J Assist Reprod Genet
November 2024
Article Synopsis
- Male infertility can be caused by various factors, including genetic mutations leading to structural sperm defects known as teratozoospermia, which affect sperm count and motility.
- A literature review categorized genes associated with sperm defects based on the types of abnormalities they cause and the evidence from human studies alongside mouse models.
- The review identified 31 genes causing defects in sperm heads and 62 genes linked to sperm tail defects, highlighting the complex genetic basis of teratozoospermia.
The atypical cadherin FAT1 function either as a pro or antitumorigenic in tumors of different tissue origins. Our group previously demonstrated the protumorigenic nature of FAT1 signaling in glioblastoma (GBM). In this study, we investigated how FAT1 influences the expression of clustered oncomiRs (miR-221-3p/miR-222-3p) and their downstream effects in GBM.
View Article and Find Full Text PDFFAT atypical cadherin 1 (FAT1) promotes glioblastoma (GBM) by promoting protumorigenic inflammatory cytokine expression in tumor cells. However, tumors also have an immunosuppressive microenvironment maintained by mediators such as transforming growth factor (TGF)-β cytokines. Here, we have studied the role of FAT1 in tumor immune suppression.
View Article and Find Full Text PDFA recent study in Scientific Reports identified glypican-3 (GPC3) as a novel extracellular interacting protein for FAT1 in hepato-cellular carcinoma (HCC) cells. FAT1 is a large transmembrane atypical cadherin with limited knowledge existing about its binding partners. While in Drosophila, dachsous (ds), another transmembrane member of the cadherin superfamily, is known to function as FAT1 ligand, no ligand is known in mammals so far.
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