[Impact of antihypertensive therapy on clinical status and quality of life in patients with initial manifestations of hypertensive encephalopathy].

Aim: To study the clinical and instrumental characteristics of hypertensive encephalopathy (HE) in early stages, as well as the time course of their changes during long-term antihypertensive therapy (AHT).

Subjects And Methods: Prior to and after 9-month AHT, 57 patients aged 50-70 years who had uncomplicated grades 1-2 arterial hypertension (AH) with grades I-II HE underwent comprehensive examination comprising the studies of cognitive functions, quality of life (QL), hemorheology, and hemostasis, duplex scanning of great and intracerebral vessels, echocardiography, 24-hour blood pressure monitoring, magnetic resonance imaging.

Results: Early-stage HE was characterized by more cerebral complaints, higher rates of hypertensive crises, a greater degree of psychoautonomic syndrome, and worse QL.

[Risk factors of vascular brain disorders in patients with diabetes mellitus].

Several studies of patients with diabetes mellitus were analyzed in review. The aim of these studies was to determine the most significant risk factors of vascular brain disorders. The pattern and peculiarities of microvascular disorders which progress simultaneously with changes in brain vessels are discussed.

[Retrospective analysis of cerebrovascular disorders in patients with lesions of the major arteries of the head].

378 cases of cerebrovascular disorders with the history of apoplexy were analyzed retrospectively. It was found that initial symptoms of cerebrovascular insufficiency occurred in 7.4%, episodes of cerebrovascular failure were registered in 31.

[Physical activity and physical work capacity of patients with initial manifestations of cerebrovascular disorders in arterial hypertension].

The routine protocol of general and neurological examinations and some special questionnaires were used to examine physical activity (FA) and physical working capacity (FWC) in a random population from one of the Moscow districts which included 1200 persons (males and females aged 30-64 years). The majority of the examinees were those who had slight and moderate exercises, mainly sitting work, did few or no physical exercises. The proportion of persons with low physical activity increased with age both among males and females.

[Neurological aspects of medical ecology].

The paper deals with a number of problems facing clinical neurology. They arise in neurological disorders stemming from unfavourable ecological conditions.

[Characteristics of cerebral hemodynamics and the resistance to major cardiovascular diseases based on the data of an epidemiologic survey].

In the cross-sectional population study of 411 subjects aged 35-64 years and longitudinal 5.5-year follow-up of 157 aged 20-54 years, a relationship was examined between pulse blood flow to the cerebral vessels, their tone as assessed by rheoencephalography and resistance to arterial hypertension, coronary heart disease, and brain vascular lesions. The proportion of healthy persons (without the above-mentioned diseases) was shown to be larger if the pulse blood flow to the cerebral vessels was higher and their tone was lower.

[Effectiveness of a stroke prevention program in a high-risk group].

As a result of screening of males born in 1922-1931 (n = 2435) a group with a high risk for stroke development (n = 620) was identified. A total of 430 of these patients were followed up for 2 years. At the final stage the authors collected data on 80% of the patients who had undergone the primary examination and carried out a new screening of age-matched males.