[Use of long-acting contraceptives in the treatment of mastopathy].

Effects of long-acting contraceptives on mammary glands of patients with diffuse fibrocystic mastopathy were under study. A total of 206 women aged 17 to 38 were examined. In 50 of them fibrocystic mastopathy was detected by palpation, non-contrast mammography, and ultrasonic examination.

[The Depo-Provera treatment of mastopathy patients].

35 women with diffuse fibrous-cystic mastopathy were treated with gestagen slow-releasing drug "Depo-Provera". Use of the drug made part of the patients feel better and promoted regression of objective signs of the disease. Conclusion was made that administration of the drug in mastopathy caused by hormonal disorders is pathogenetically substantiated method of treatment.

[The effect of nizoral on the function of the hypothalamo-hypophyseal-ovarian system in virilism].

A study is presented of the effect of nisoral on the hypothalamo-pituitary-ovarian system in 25 patients with hyperandrogenism (ovarian in 11, suprarenal in 14). It was established that most patients with oligomenorrhea and anovulation showed a restoration of the menstrual cycle after the 2-3 treatment courses and also absence of progression and reduction of the rate of pathological hair growth. After nisoral treatment the testosterone level decreased while estradiol and progesterone increased, gonadotropins remained unchanged, urinary excretion of 17-ketosteroids reduced.

[The treatment of the climacteric syndrome in women suffering from Itsenko-Cushing disease and primary obesity].

Results are reported of an investigation of the hypothalamo-pituitary-ovarian-adrenal system in 51 women suffering of Itsenko-Cushing disease, primary obesity and menopausal syndrome. It was found that with onset of the menopause there occurs an increase of the concentration of lutropin, follitropin, testosterone and a reduction of the level of estradiol as in the control group. At the same time the level of prolactin and cortisol was increased as compared with the control group.

[The gonadotropin, prolactin and sex steroid content of the blood from the inferior cavernous sinuses and the adrenal and ovarian veins of women with Itsenko-Cushing disease].

Results are reported of a study of the content of gonadotropins, prolactin and sex steroids in different regions of the vascular bed in women with Itsenko-Cushing disease. It was found that the content of gonadotropins were similar at all levels of the vascular bed indicating their secretion reduction in the pituitary. At the same time there was an increase of prolactin, testosterone, progesterone and cortisol in the blood of the ovarian, adrenal, peripheral and lower cavernous sinus veins.

[Characteristics of the course of pregnancy and labor in women with Cushing's syndrome and the condition of their progeny].

An analysis of gestational and obstetric histories of 40 women with Cushing's disease has shown that pregnancy is contraindicated during an active phase or partial clinical remission of the disease. Pregnancy is permissible at a prolonged time following the onset of a stable clinical and hormonal remission, bilateral total adrenalectomy and compensation of chronic adrenal insufficiency. No specific therapy is required in the former situation.

[Indices of the functional state of the hypothalamus-hypophysis-ovaries system in women with Itsenko-Cushing disease].

The content of gonadotropic hormones, prolactin and sex steroids were examined in the blood of 97 women with Itsenko-Cushing disease before and after administration of LH-RH and chorionic gonadotropin hormone. It was found that women with Itsenko-Cushing disease revealed a reduced concentration of gonadotropic hormones while the level of testosterone, progesterone, prolactin was increased. Estradiol remained unchanged.

[The effect of thyroliberin on the blood level of gonadotropins and sex steroids in women suffering from Itsenko-Cushing disease].

The authors examined the level of gonadotropin (lutropin, follitropin) and sex steroids (estradiol, progesteron, testosterone) before and after administration of thyroliberin in 10 healthy women and 15 females suffering of Itsenko-Cushing disease. It was established that both the healthy and patients with Itsenko-Cushing disease did not reveal any significant changes in the level of lutropin, follitropin, estradiol, progesteron, testosteron after administration of thyroliberin within 2 hours of the examination. Data indicate absence of paradoxic response of gonadotropins and cells secreting sex steroids in Itsenko-Cushing disease.

[Effect of the treatment of Cushing's syndrome and primary obesity on the female reproductive system].

Basic parameters of the reproductive system were examined in 121 women with Icenko-Cushing's disease and in 87 ones with primary obesity before and after therapy. Icenko-Cushing's disease was treated with the means acting on the adrenals (chloditan, destruction of one or both adrenals, uni- or bilateral adrenalectomy) and on the hypothalamohypophyseal area (parlodel, peritol, nakom, R-therapy). Combined therapy of primary obesity included low-caloric diet (approximately 1200 kcal) with 1-2 fasting days weekly, a complex of therapeutic exercises, physio- and balneotherapy.

[Disorders of hypothalamico-pituitary regulation of adrenal and ovarian function in women suffering from Itsenko-Cushing disease].

Data are reported of the functional state of the hypothalamoadrenal system in 119 women with Itsenko-Cushing disease in the active stage, stage of stable clinical remission and after total adrenalectomy. It was established that the most pronounced changes of the relationship of pituitary, adrenal, uterine hormones were found in the active stage of the disease. This leads to disorders of the menstrual cycle according to the type of hypomenstrual syndrome, polycystic degeneration of the ovaries and infertility.

[Dynamics of the corticotropin, cortisol and prolactin content of the blood plasma of women with Itsenko-Cushing disease administered luliberin].

The paper is concerned with the results of a study of the level of plasma ACTH, cortisol and prolactin before and after i. v. injection of LHRH to 20 patients with Itsenko-Cushing disease and to 5 healthy persons.

[Plasma level of testosterone-estradiol-binding globulin in women with Itsenko-Cushing disease].

A total of 50 patients with Icenko-Cushing's disease were examined for the levels of estradiol, testosterone and testosterone-binding globulin in various stages of the disease. In disease recurrences the levels of testosterone were two-fold higher than those in normal subjects versus the testosterone-estradiol-binding capacity (TEBC) in the blood serum which was decreased in patients with Icenko-Cushing's disease. During remission the levels of testosterone decreased, those of the blood TEBC increased, but however failed to achieve their values in health.

[Testosterone content of the blood in women with Itsenko-Cushing disease].

The paper is concerned with the results of a study of the testosterone content in the blood of 68 women with the Itsenko-Cushing disease at different stages of therapy. The testosterone level was elevated in the blood of untreated patients at the stage of exacerbation and remission following various therapeutic modalities including khloditan and returned to normal after bilateral total adrenalectomy. It is assumed that the source of testosterone hyperproduction in the Itsenko-Cushing disease is the adrenals.

[Interrelation of disorders in gonadotropin and prolactin secretion and the activity of the hypothalamo-hypophyseal-adrenal system in Itsenko-Cushing disease].

An obvious relationship between changes in ACTH, gonadotrophin, prolactin and cortisol secretion was discovered on the basis of studying the basal ACTH, cortisol, LH, FSH and prolactin levels, as well as from correlative examination of the data obtained in 30 females with Icenko-Cushing's diseases. It is suggested that combined ACTH, gonadotrophin and prolactin secretion occurs in the active stage of the disease, whereas cortisol inhibits gonadotrophin production. A degree of gonadotrophic insufficiency is dependent on the ratio of excessive ACTH-cortisol secretion.