Publications by authors named "Manus J"
Rationale: Therapies that inhibit CETP (cholesteryl ester transfer protein) have failed to demonstrate a reduction in risk for coronary heart disease (CHD). Human DNA sequence variants that truncate the gene may provide insight into the efficacy of CETP inhibition.
Objective: To test whether protein-truncating variants (PTVs) at the gene were associated with plasma lipid levels and CHD.
Article Synopsis
- * It involved analyzing genetic data from multiple cohorts to identify both rare damaging mutations and common variants associated with lipid levels and CAD risk.
- * Results show that a small percentage of individuals carried damaging mutations in LPL, and these carriers had higher triglyceride levels compared to noncarriers.