Publications by authors named "Manuella Djomaleu"
From 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) household transmission studies (enrolling April 2020 to January 2022) with rapid enrollment and specimen collection for 14 days, 61% (43/70) of primary cases had culturable virus detected ≥6 days post-onset. Risk of secondary infection among household contacts tended to be greater when primary cases had culturable virus detected after onset. Regardless of duration of culturable virus, most secondary infections (70%, 28/40) had serial intervals <6 days, suggesting early transmission.
View Article and Find Full Text PDFThe 2013-2016 Ebola virus disease (EVD) epidemic caused food insecurity during and immediately following local outbreaks in Sierra Leone, but longer-term effects are less well described, particularly among households with no EVD survivors. We conducted a qualitative sub-study in July 2018 in Kono District, Sierra Leone to understand the impact of food insecurity on EVD-affected households. Using data from a community-based cohort, we compiled a list of all households, within the sampled communities in Kono District, that had at least one EVD case during the epidemic.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated how vaccination affects the infectiousness of SARS-CoV-2 by comparing viral shedding in unvaccinated and fully vaccinated adults who tested positive for the virus.
- Although maximum RNA levels in both groups were similar, vaccinated individuals showed a quicker decline in viral load and had a shorter duration of infectious virus.
- Specifically, vaccinated participants had a median infectious virus detection duration of 6 days compared to 7.5 days in unvaccinated individuals, showing that vaccination reduces the likelihood of spreading the virus after the first five days of symptoms.
Background: Households have emerged as important venues for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission. Little is known, however, regarding the magnitude and determinants of household transmission in increasingly vaccinated populations.
Methods: From September 2020 to January 2022, symptomatic nonhospitalized individuals with SARS-CoV-2 infection by RNA detection were identified within 5 days of symptom onset; all individuals resided with at least 1 other SARS-CoV-2-uninfected household member.