Publications by authors named "Manuele Novello"
Article Synopsis
- Respiration is critical for life, regulated by the brain to meet metabolic demands, coordinating breathing with body movement and posture.
- * The brainstem central pattern generator works within a larger network that includes the cerebellum, which plays a key role in coordinating motor control and autonomic functions.
- * This review explores the anatomical and functional interactions of brain regions in respiratory control, the impact of sensory feedback, and how disorders can disrupt these mechanisms.
The cerebellum is involved in many motor, autonomic and cognitive functions, and new tasks that have a cerebellar contribution are discovered on a regular basis. Simultaneously, our insight into the functional compartmentalization of the cerebellum has markedly improved. Additionally, studies on cerebellar output pathways have seen a renaissance due to the development of viral tracing techniques.
View Article and Find Full Text PDFMost studies investigating the impact of the cerebral cortex (CC) onto the cerebellum highlight the role of the pons, which provides the mossy fibers to the cerebellum. However, cerebro-cerebellar communication may also be mediated by the nuclei of the mesodiencephalic junction (MDJ) that project to the inferior olive (IO), which in turn provides the climbing fibers to the molecular layer. Here, we uncover the precise topographic relations of the inputs and outputs of the MDJ using multiple, classical, and transneuronal tracing methods as well as analyses of mesoscale cortical injections from Allen Mouse Brain.
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