Publications by authors named "Manuela Rocha Bueno"

Oral bacteria are implicated not only in oral diseases but also in gut dysbiosis and inflammatory conditions throughout the body. The periodontal pathogen () often occurs in complex oral biofilms with (), and this interaction might influence the pathogenic potential of this pathogen. This study aims to assess the impact of oral inoculation with , , and their association (+) on alveolar bone loss, oral microbiome, and their potential effects on intestinal health in a murine model.

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Article Synopsis
  • * Treatment with CNV at the highest concentration (1600 μg/mL) significantly reduced more bacterial species compared to amoxicillin (25 vs. 13 species) and showed a superior effect in decreasing the metabolic activity of the biofilm.
  • * The findings suggest that CNV could be a promising alternative for managing dental biofilms and reducing their harmful effects, outperforming traditional antibiotic treatment.
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The oral cavity harbors hundreds of microorganisms that may be uncontrolled and provoke several diseases. In this sense, periodontitis is a complex multifactorial disease with an essential microbial component in its etiology. Periodontal treatment involves mechanical control of the supra- and subgingival biofilm, but not all patients respond predictably to treatment.

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The isoflavone (3)-vestitol, obtained from red propolis, has exhibited anti-inflammatory, antimicrobial, and anti-caries activity; however, few manuscripts deal with its anti-inflammatory mechanisms in macrophages. The objective is to elucidate the anti-inflammatory mechanisms of (3)-vestitol on those cells. Peritoneal macrophages of C57BL6 mice, stimulated with lipopolysaccharide, were treated with 0.

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Clinical features suggest differences in immune response among periodontitis forms, albeit a large number of cytokines and chemokines remain to be evaluated. The saliva is an available source of mediators and its analysis would be valuable in order to understand pathophysiological differences. The objective of this study was analyze chemokines/cytokines profile in whole saliva of individuals with severe periodontitis (Stage III) presenting moderate [Grade B; GB] or rapid progression rate with a localized incisor-molar pattern [Grade C; GC/IMP].

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Background: This study aimed to evaluate, histomorphometrically, the use of collagen matrix (CM) and/or enamel matrix derivative (EMD) for the treatment of dehiscence-type recession defects in minipigs.

Methods: Eight healthy, male, young BR-1 minipigs, with no periodontal disease were treated. Bilateral dehiscence-type defects were surgically created on the buccal of the mandibular premolars (PI and PII).

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Objectives: To evaluate the treatment of gingival recessions by semilunar coronally positioned flap plus enamel matrix derivative (SCPF + EMD).

Materials And Methods: Thirty patients with class I localized gingival recession were included. They were randomly allocated in two groups: SCPF + EMD and SCPF.

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