Publications by authors named "Manuela Pereira-Abrantes"
Myeloid cell infiltration of solid tumours generally associates with poor patient prognosis and disease severity. Therefore, understanding the regulation of myeloid cell differentiation during cancer is crucial to counteract their pro-tumourigenic role. Bone marrow (BM) haematopoiesis is a tightly regulated process for the production of all immune cells in accordance to tissue needs.
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- Platelets interact with neutrophils to form neutrophil-platelet aggregates (NPAs), which enhance neutrophil functions during inflammation and may worsen various inflammatory diseases, including cancer.
- Research using advanced imaging techniques revealed that NPAs are primarily formed through platelets binding to low-density neutrophils (LDNs) in both healthy individuals and cancer patients.
- Analyzing the genetic profile of NPAs indicated a unique molecular signature linked to neutrophil activation and worse prognosis in cancer patients, suggesting NPAs could serve as a valuable noninvasive biomarker for monitoring cancer progression.
Neutrophils have been extensively described in the pathophysiology of autoimmune and infectious diseases. Accumulating evidence also suggests the important role of neutrophils in cancer progression through their interaction with cancer and immune cells in blood and in the tumor microenvironment (TME). Most studies have described neutrophils as key drivers of cancer progression, due to their involvement in various tumor promoting functions including proliferation, aggressiveness, and dissemination, as well as in immune suppression.
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