Genotoxic parameters of human degenerated intervertebral discs are linked to the pathogenesis of disc degeneration.

Background: Degenerative disc disease (DDD) is a prevalent disorder that brings great incapacity and morbidity to the world's population. Its pathophysiology is not fully understood. DNA damage can influence this process, but so far, there have been few studies to evaluate this topic and its true importance in DDD, as well as whether there is a relation between degeneration grade and DNA damage.

Hyaluronic Acid Response: Viability and Proliferation Profile of Human Chondrocytes in 3D-Based Culture.

Objectives: This study aimed to evaluate the efficacy of hyaluronic acid in the viability and proliferation profile of human femoral-tibial joint cartilage affected by osteoarthritis using models of chondrocytes in a 2-dimensional (2D)- and 3-dimensional (3D)-based culture model by spheroids.

Design: In vitro study of knee cartilage affected by osteoarthritis that required surgical treatment. Samples were cultured and exposed to hyaluronic acid (100 and 500 μM; intervention group) or vehicle solution.

Hyperbaric Oxygen Therapy After Acute Thoracic Spinal Cord Injury: Improvement of Locomotor Recovery in Rats.

Study Design: A controlled laboratory study.

Objective: The aim of this study was to analyze the effectiveness of hyperbaric therapy (HT) using mild and moderate models of spinal cord injury (SCI).

Summary Of Background Data: SCI can cause permanent impairment with socioeconomic consequences.