Severe sperm DNA fragmentation may persist for up to 3 years after cytotoxic therapy in patients affected by Hodgkin lymphoma and non-Hodgkin lymphoma.

Study Question: Does sperm DNA recover from damage in all men after 2 years from the end of cytotoxic treatments?

Summary Answer: The current indication of 2 years waiting time for seeking natural pregnancy after cytotoxic treatment may not be adequate for all men, since severe sperm DNA damage is present in a proportion of subjects even after this timeframe.

What Is Known Already: Data in the literature on sperm DNA fragmentation (SDF) in lymphoma patients after cytotoxic treatments are scarce. The largest longitudinal study evaluated paired pre- and post-therapy (up to 24 months) semen samples from 34 patients while one study performed a longer follow-up (36 months) in 10 patients.

Psychobiological Correlates of Vaginismus: An Exploratory Analysis.

Background: Evidence concerning the determinants of vaginismus (V), in particular medical conditions, is inconclusive.

Aim: To investigate, in a cohort of subjects consulting for female sexual dysfunction, whether there is a difference in medical and psychosocial parameters between women with V and women with other sexual complaints.

Methods: A series of 255 women attending our clinic for female sexual dysfunction was consecutively recruited.