CDKL5-associated developmental and epileptic encephalopathy: A long-term, longitudinal electroclinical study of 22 cases.

Objective: The study was conducted to analyze the possible diagnostic value of the electroclinical semiology of the epileptic seizures.

Methods: We evaluated the medical records of 17 females and 5 males with CDKL5 deficiency disorder (CDD) considering the long-term evolution, including the polygraphic video-EEG recordings.

Results: We recognized three disease phases.