Publications by authors named "Manuela Lo Porto"
Article Synopsis
- Increased levels of soluble urokinase-type plasminogen activator receptor (suPAR) are linked to focal segmental glomerulosclerosis and other kidney-related diseases, including HIV and diabetes.
- Full-length suPAR reduces nephrin expression in human podocytes, impacting kidney function and is dependent on time and dosage as well as the inhibition of the WT-1 transcription factor.
- Studies in a mouse model reveal that suPAR causes decreased nephrin and WT-1 expression, leading to proteinuria, highlighting its role in kidney diseases with elevated suPAR levels.
