Publications by authors named "Manuel-Gerardo Rosales-Gonzalez"
Tannic Acid, as a Structural Moiety Coupled to a Protein Antigen, Exhibiting a Molecular-structure Adjuvant Activity for Antibody Specificity Enhancement.
Brenda Molina-Ramírez Nidia Cabral-Hipólito Irais Castillo-Maldonado Dealmy Delgadillo-Guzmán Rocío Meza-Velázquez
Protein Pept Lett
November 2022
Article Synopsis
- Antigens are foreign substances that can trigger an immune response, and new adjuvants like tannic acid (TA) are needed to enhance this response because not all antigens are effective on their own.
- The study evaluated the effect of TA as an adjuvant when combined with bovine serum albumin (BSA) in Balb/c mice, using various immunization methods and tests to assess humoral and cell-mediated immunity.
- Results indicated that while there was no difference in overall antibody levels, the mixture of TA and BSA significantly improved specific antibody responses and activated macrophages, suggesting that TA can enhance the immunogenicity of protein antigens.
Background: Inhaled glucocorticoids are the most effective and potent drugs used to control the inflammatory bronchial reaction in patients with asthma. There are several research projects evaluating the use of immune modulators in the treatment of the asthma related inflammatory process.
Objective: To evaluate the effect of transfer factor in the treatment of pediatric patients with moderate persistent allergic asthma in terms of inhaled glucocorticoid dosing and time of using.