Publications by authors named "Manuel de Gracia Blanco"
Article Synopsis
- Neuroscience clinical trials often fail, so choosing the right outcomes early on is really important for finding new treatments in mental and brain health.
- A group called The Outcomes Research Group is trying to create better ways to pick outcomes for these trials to improve the chances of success.
- This article gives guidelines on how to standardize the process for choosing outcomes in neuroscience research, helping researchers do better work and avoid risks.
Background and Objective. Most patients with fibromyalgia benefit from different forms of physical exercise. Studies show that exercise can help restore the body's neurochemical balance and that it triggers a positive emotional state.
View Article and Find Full Text PDFObjectives: Anosognosia is the lack of deficit awareness, and it is a common symptom in patients with Alzheimer's disease (AD). The objective of this study was to assess the relationship between anosognosia and caregiver burden.
Methods: This was a cross-sectional, analytical study of patients who were diagnosed with AD and their caregivers.
Objectives: to determine the prevalence of three independent, disability-free and operationally defined frailty phenotypes and the associated risk of mortality in a community-dwelling older people cohort over 74 years of age.
Methods: observational, prospective and population-based design. Bio-psycho-social variables were assessed using a range of standardised instruments.
This study aimed to identify the differences in body self-esteem, general self-esteem and eating attitudes in a representative sample of children, aged 9-12 years, attending school in México DF. The logistic regression model incorporated the variables of sex, general self-esteem, BMI, age and discrepancy between the perceived image and the ideal image. Participants with an increased risk of eating disorders were girls: a) with less general self-esteem; b) BMI at the upper range of normal weight; c) greater negative discrepancy between perceived and ideal image; d) aged 11-12 years.
View Article and Find Full Text PDFBehavioral and psychological symptoms of dementia (BPSD) are frequently observed in Alzheimer's disease (AD) and affect more than 80% of patients over the course of AD. The goal of this study was to establish a model for grouping the symptoms of BPSD into clinical syndromes. Over a 24-month period, an observational study was conducted using a population of ambulatory patients with AD of mild to moderate severity.
View Article and Find Full Text PDFBehavioral and psychological symptoms of dementia (BPSD) are characterized by fluctuations in their frequency and severity as well as by differences in the concurrent presentation of different symptoms. The goal of the current study was to identify groups of patients with Alzheimer's disease (AD) that had similar trajectories in the expression of BPSD. Over a 24-month period, an observational study was conducted using a population of ambulatory patients with AD of mild or moderate severity.
View Article and Find Full Text PDFObjective: To obtain an updated FIQ consensus version for patients in Spain, the Cuestionario de Impacto de la Fibromialgia (CIF).
Material And Methods: The CIF elaboration was carried out with the participation of all the groups of researchers in the 4 previous FIQ Spanish versions, and taking into account the recent updated version of the original FIQ. The CIF was completed by a sample of fibromialgia patients to explore how comprensible its items are and to compare its global score with 2 fibromialgia composite severity indexes, one semi-objective and one subjective.