DNA methylation biomarkers of myocardial infarction and cardiovascular disease.

Background: The epigenetic landscape underlying cardiovascular disease (CVD) is not completely understood and the clinical value of the identified biomarkers is still limited. We aimed to identify differentially methylated loci associated with acute myocardial infarction (AMI) and assess their validity as predictive and causal biomarkers.

Results: We designed a case-control, two-stage, epigenome-wide association study on AMI (n = 391, n = 204).