Publications by authors named "Manuel Valenzuela-Barranco"
In the last years,several studies have focused on the involement of vitamin D in different physiological and pathological processes. One of the most interesting actions occurs in the Inflammatory bowel disease, where a higher prevalence of vitamin D deficiency has been observed. This study aimed to review the literature in order to explain its relationship with the disease, the risk factors, measuring the importance of sun exposure, describing how treatments are affected or observing the effect of vitamin supplementation in this type of patients.
View Article and Find Full Text PDFBochdalek hernias (BHs) are produced in the posterolateral area of the diaphragm. They are generally congenital, appearing in childhood, but are also detected in asymptomatic adult patients seeking medical attention for other reasons. Computed tomography (CT) or magnetic resonance imaging (MRI) is used for the correct diagnosis of the hernia type and for its localization, facilitating its management and the choice of treatment.
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- Cyclic GMP is crucial for keeping the gastric mucosa healthy, and NSAIDs can harm this protective lining by lowering cyclic GMP levels.
- The study tested various NSAIDs on rats and discovered that higher doses led to lower cyclic GMP levels, which correlated with more significant mucosal damage.
- However, when rats were given phosphodiesterase inhibitors like zaprinast or IBMX, the cyclic GMP levels remained normal, and no gastric damage occurred, supporting the idea that cyclic GMP is key to NSAID-related gastric injury.