Synopsis of recent research by authors named "Manuel Thieme"
- Manuel Thieme's research primarily focuses on the regulation of renal blood flow and systemic blood pressure, particularly exploring the roles of nitric oxide-sensitive guanylyl cyclases and various signaling pathways involved in hypertension.
- His studies indicate that different isoforms of guanylyl cyclase (NO-GC1 and NO-GC2) play distinct roles in modulating renal hemodynamics, with specific knockout models revealing differential effects on blood pressure regulation.
- Additionally, Thieme's research highlights the impact of phosphodiesterase inhibition on angiotensin II-induced hypertension and the complexities of endothelial nitric oxide synthase (eNOS) in blood pressure control, demonstrating that endothelial-specific rescue of eNOS does not fully restore blood pressure homeostasis in deficient models.
