Publications by authors named "Manuel Sanchez-Diaz"

Genetic trends are a valuable tool for analysing the efficiency of breeding programs. They are calculated by averaging the predicted breeding values for all individuals born within a specific time period. Moreover, partitioned genetic trends allow dissecting the contributions of several selection paths to overall genetic progress.

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Background And Objectives: Alopecia areata (AA) impairs quality of life. However, there is no evidence on the impact of this disease in terms of sexual dysfunction (SD). The aim of the present study was to assess the prevalence of SD and possible associated factors in a cohort of patients with AA.

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: Bullous pemphigoid (BP) is an autoimmune disease characterized by the appearance of very pruritic subepidermal blisters. It appears mostly in the elderly and is associated with multiple comorbidities, which makes its management and treatment difficult. The purpose of this systematic review is to compile current information on published cases of BP treated with omalizumab (omalizumab) and dupilumab (dupilumab) in order to obtain information on clinical efficacy and safety data available.

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Article Synopsis
  • A common nosocomial pathogen poses a significant risk to critically ill patients due to its drug resistance and potential to cause severe infections.
  • Traditional antibiotic treatments for wounds can lead to toxicity and encourage further drug resistance, highlighting the need for alternative strategies.
  • Recent research focuses on wound dressings enhanced with nanoparticles (especially silver), which may improve healing, but more clinical trials are needed to assess their effectiveness and safety in patients.
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  • Psoriasis is a chronic skin condition caused by an improper interaction between skin cells and the immune system, necessitating better understanding and models for effective treatment development.
  • A review of 45 studies identified various preclinical models of psoriasis, with in vitro models being the most common, especially three-dimensional ones that closely mimic human skin.
  • The review highlights the strengths and weaknesses of different in vivo, in vitro, and ex vivo models, emphasizing the challenges in improving these research tools for better treatment outcomes.
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Burnout syndrome is a mental health condition related to chronic occupational stress; its prevalence, as well as its relationship with other mental health disorders in physicians, has become a topic of growing interest. However, no studies with large sample sizes evaluate this association in dermatologists. With this background, a cross-sectional study was designed, which included 420 Spanish dermatologists; the mean age was 44.

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Psoriasis is a chronic inflammatory disease associated with significant impairment in quality of life. Although quality of life in patients with psoriasis has been widely studied, there is little evidence regarding the impact of psoriasis on major life-changing decisions (MLCD). The aims of this study are to describe the impact of psoriasis on MLCD and to explore the potential clinical factors associated with MLCD.

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  • Chronic spontaneous urticaria (CSU) can make people feel sad and have a lower quality of life, especially affecting women more than men.
  • A study with 75 patients found that over half of them had sexual dysfunction, which made their condition feel even worse.
  • Women with sexual dysfunction and poorly controlled CSU were at a higher risk for anxiety and depression, suggesting that doctors should check for these issues to help patients feel better.
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Skin barrier dysfunction plays an important role in atopic dermatitis (AD) aetiopathogenesis. Dupilumab, a drug that inhibits IL-4 and IL-13, is an effective treatment for AD but there is scarce evidence about its impact on epidermal barrier. The objective of this systematic review is to evaluate the influence of dupilumab on skin barrier in patients with AD using non-invasive tools.

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  • Hidradenitis suppurativa (HS) is a chronic skin condition, and secukinumab, a biologic drug, is being studied for its effectiveness and safety in treating moderate to severe cases over 16 weeks.
  • A study involving 47 patients in southern Spain found that nearly 49% achieved significant clinical improvement (HiSCR) after treatment, with only a small percentage experiencing adverse effects.
  • Factors such as being female, having a lower body mass index (BMI), and a lower previous treatment burden were linked to a higher likelihood of achieving the desired treatment response.
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Chronic Spontaneous Urticaria (CSU) leads to a decreased quality of life in patients because of pruritus and skin lesions. However, there is still little evidence on the impact that a worse sleep quality could have on the quality of life and emotional disorders in these patients. The aims of the present study are to analyze the potential impact of sleep quality on the quality-of-life and emotional status of patients with CSU.

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  • Hidradenitis suppurativa (HS) is associated with increased cardiovascular risk (CVR) due to inflammation, and this study investigates how adalimumab treatment affects patients' CVR.
  • In a study involving 27 patients with severe HS, while overall carotid intima-media thickness (IMT) showed no significant change after 32 weeks, 40.7% of patients improved their IMT.
  • The patients who improved had more classic CVR factors like dyslipidemia and diabetes, suggesting that those with higher atherosclerosis burden and less inflammation might respond better to adalimumab treatment.
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Type D personality is characterized by social inhibition and negative affectivity. Poorer outcomes and worse quality of life have been linked to type D personality in patients with a variety of non-dermatological diseases. Despite increasing evidence of the importance of type D personality in skin diseases, there are no reviews on this subject.

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A poor quality of life has been described in patients suffering from Alopecia Areata (AA). However, there is little evidence on how AA can impact on those living with patients. The aim of this study is to analyze the impact of AA on a cohabitant’s quality-of-life, mood status disturbances and sexual satisfaction.

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Background: Surgery is an essential part of hidradenitis suppurativa (HS) treatment. Understanding and reducing surgical recurrence are crucial to obtaining the best results in patients' treatment.

Objective: The aim of the study was to characterize surgical recurrences in a cohort of patients with HS treated with wide excision and second-intention healing.

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We report the case of a neonate presenting with the clinical features of blueberry muffin syndrome caused by ganglioneuroblastoma, a rare variant of neuroblastoma. This syndrome may be the only visible manifestation of a neonatal tumor and highlights the importance of early recognition and initiation of therapy to reduce mortality.

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Introduction: Distressed personality (or Type D personality, TDp) is a personality trait that has been associated with poor quality of life in patients suffering from a variety of skin diseases such as psoriasis or urticaria. To date the potential association between Alopecia areata (AA) and TDp has not been studied. The aim of this study was to compare the prevalence of TDp between patients with AA and controls, and to analyse the impact of TDp on patients with AA regarding mood status disturbances, quality of life and sexuality.

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Alopecia Areata (AA) is a chronic condition which has been associated with poor quality of life and mood status disturbances. The aim of this study is to compare the sleep quality between AA patients and controls, and to analyze the impact of poor sleep quality on patients with AA regarding mood status disturbances, quality of life and sexuality. A cross-sectional study including patients suffering from mild-to-severe AA and sex- and age-matched healthy controls was performed.

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Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the hair follicle that has previously been associated with a higher cardiovascular risk (CVR). Although different methods have been described for CVR stratification in HS, there is little evidence about the role of hemogram indexes in CVR in HS. Given its potential convenience, the aim of this study was to assess the role of the hemogram indexes systemic immune-inflammation index (SII) and neutrophil-lymphocyte ratio (NLR) in CVR stratification for patients with HS.

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Article Synopsis
  • Hidradenitis suppurativa (HS) is a chronic skin condition causing painful lumps and lesions, typically treated with antibiotics and biologics; however, managing the disease remains difficult, leading to the consideration of acitretin as a 3rd or 4th line therapy.
  • A study involving 62 patients showed that acitretin significantly improved HS severity scores over time, with some potential predictors of a positive response identified, such as higher baseline severity and certain family histories.
  • Most patients tolerated acitretin well and experienced no severe side effects, although some discontinued treatment due to insufficient effectiveness, indicating that acitretin may be a viable option for HS management.
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Background: Early detection of melanoma is one of the main diagnostic goals of dermatologists worldwide, due to the increasing incidence of the disease in our environment. However, the irruption of the SARS-CoV-2 pandemic has posed a challenge to global healthcare, forcing systems to focus their resources on the fight against COVID-19. Methods: Retrospective cohort study.

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Chronic Spontaneous Urticaria (CSU) has been associated with patients’ poor quality of life. Despite being a chronic disease that could alter the quality of life of the people who live with patients, the potential burden on their cohabitants has not been studied to date. The aim of this study is to analyze the relationship between the patient’s quality of life, disease control, disease duration and family quality of life and the cohabitant’s mood disturbances, sexual dysfunction, type D personality and sleep quality.

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