Methemoglobinemia With Dapsone Prophylaxis in a Patient With Minimal Change Disease.

Our case report represents the need to maintain vigilance for methemoglobinemia risk in patients without classic symptoms, specifically, in patients that develop shortness of breath after starting prophylaxis for pneumonia, mostly with dapsone. A case report of a 42-year-old male with minimal change disease nephrotic syndrome required pneumonia prophylaxis due to high-dose systemic steroids. The patient was started on dapsone due to side effects and the availability of alternative medications.

Dendritic Cell Protection from Cisplatin Nephrotoxicity Is Independent of Neutrophils.

Cisplatin is a very effective chemotherapeutic agent used against a wide range of solid tumors. A major adverse effect of cisplatin therapy is acute kidney injury (AKI). Neutrophils are reported to infiltrate and exacerbate injury in a wide range of sterile inflammatory models of tissue injury.