Quantitative brain [F]FDG PET beyond normal blood glucose levels.

Introduction SUV measurements from static brain [F]FDG PET acquisitions are a commonly used tool in preclinical research, providing a simple alternative for kinetic modelling, which requires complex and time-consuming dynamic acquisitions. However, SUV can be severely affected by the animal handling and preconditioning protocols, primarily by those that may induce changes in blood glucose levels (BGL). Here, we aimed at developing and investigating the feasibility of SUV-based approaches for a wide range of BGL far beyond normal values, and consequently, to develop and validate a new model to generate standardized and reproducible SUV measurements for any BGL.

A Systematic Review of PET Textural Analysis and Radiomics in Cancer.

Background: Although many works have supported the utility of PET radiomics, several authors have raised concerns over the robustness and replicability of the results. This study aimed to perform a systematic review on the topic of PET radiomics and the used methodologies.

Methods: PubMed was searched up to 15 October 2020.

Is FDG-PET texture analysis related to intratumor biological heterogeneity in lung cancer?

Objectives: We aimed at investigating the origin of the correlations between tumor volume and F-FDG-PET texture indices in lung cancer.

Methods: Eighty-five consecutive patients with newly diagnosed non-small cell lung cancer (NSCLC) underwent a F-FDG-PET/CT scan before treatment. Seven phantom spheres uniformly filled with F-FDG, and covering a range of activities and volumes similar to that found in lung tumors, were also scanned.

Spill-in counts in the quantification of F-florbetapir on Aβ-negative subjects: the effect of including white matter in the reference region.

Background: We aim to provide a systematic study of the impact of white matter (WM) spill-in on the calculation of standardized uptake value ratios (SUVRs) on Aβ-negative subjects, and we study the effect of including WM in the reference region as a compensation. In addition, different partial volume correction (PVC) methods are applied and evaluated.

Methods: We evaluated magnetic resonance imaging and F-AV-45 positron emission tomography data from 122 cognitively normal (CN) patients recruited at the Alzheimer's Disease Neuroimaging Initiative (ADNI).