Identification of a metabolic and canonical biomarker signature in Mexican HR+/HER2-, triple positive and triple-negative breast cancer patients.

Infiltrating ductal breast cancer (IDC) is the principal tumor associated-malignancy in Mexican women. In IDC, the development of intermittent hypoxia leads to an adaptive response coordinated by the transcriptional factor HIF-1α. In the present pilot, retrospective/cross-sectional study, the HIF-1α expression was analyzed in 102 tru-cut biopsies from female patients (51 ± 12 years) without previous clinical treatment and compared to 31 normal breast biopsies.

Her-2/neu expression as a predictive factor for response to anthracycline-based chemotherapy in a mexican population of locally advanced breast cancer patients.

Breast cancer is the second most frequent tumor in Mexico 30-50% are diagnosed in locally advanced stages requiring neoadjuvant chemotherapy. The overexpression of HER-2/neu has been identified as a chemotherapy response predictor. The objective of our study was to identify response predictive factors to anthracycline-based neoadjuvant chemotherapy in locally advanced breast cancer.

[Appendicitis following esophagogastroduodenal study: report of a case].

Retention of barium within appendix following a gastrointestinal tract study may predispose in rare instances to narrowing of appendiceal lumen, thus contributing to development of acute appendicitis. We present the case of a 42-year-old woman in whom this sequence of events was recognized who presented with clinical signs of acute appendicitis 9 days after barium swallow test was performed. Patients must be informed increased chance for development of appendicitis in these cases and be instructed to recognize early symptoms.