Publications by authors named "Manuel Miras-Lopez"
The aim of this study was to characterize monocyte-derived macrophages (M-DM) from blood and ascites of cirrhotic patients comparatively with those obtained from blood of healthy controls. The phenotypic profile based on CD14/CD16 expression was analyzed by flow cytometry. Cells were isolated and stimulated in vitro with LPS and heat killed Candida albicans.
View Article and Find Full Text PDFWe present the case of a 44-year-old woman with past history of repeated miscarriage and Budd-Chiari syndrome secondary to primary myelofibrosis. Because of this she was under treatment with oral anticoagulant agents. The patient was admitted in hospital as she presented with gastrointestinal bleeding (melena), asthenia and progressive anemia.
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- The study aimed to investigate differences in the inflammatory profiles of macrophages derived from patients with cirrhosis due to either hepatitis C virus (HCV) or alcohol, focusing on their ascitic fluid.
- Patients with HCV-related cirrhosis showed distinct patterns of immune cell migration and cytokine levels in ascites, with a generally lower inflammatory response compared to alcohol-related cirrhosis.
- Findings indicated that HCV patients had higher IL-10 levels and lower levels of IL-6 and IL-12 in their ascitic fluid, while the primed status of peritoneal macrophages was maintained under laboratory conditions, with notable differences in cell signaling responses between the two patient groups.
Long-term immunosuppression may produce several severe complications, highlighting cardiovascular complications and de novo malignancies, which are the main causes for late demise not related to graft.
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