Publications by authors named "Manuel Machado-Duque"
Background: Mycophenolate mofetil is used for the prevention of solid organ transplant rejection and for other indications, such as systemic lupus erythematosus (SLE).
Objective: To determine the prescription patterns of mycophenolate mofetil in a group of Colombian patients.
Methods: This was a cross-sectional study of patients receiving mycophenolate mofetil between 2021 and 2022.
Article Synopsis
- - The study investigates the prescription patterns of noninsulin antidiabetic medications among 155,381 Colombian patients with type 2 diabetes mellitus (T2DM), primarily focusing on the most commonly prescribed drugs and their usage in combination therapy.
- - Metformin emerged as the most frequently prescribed antidiabetic, followed by empagliflozin, sitagliptin, linagliptin, and dapagliflozin, with a significant portion of patients (55.5%) receiving combinations of two or three medications.
- - Despite advancements in treatment guidelines, many T2DM patients with related cardiovascular conditions are not receiving optimal antidiabetic therapy, indicating a need for better access to drugs that might reduce cardiovascular risk, like sodium
Human immunodeficiency virus (HIV) is a global public health problem. Coinfections in HIV patients are frequent complications that increase their mortality. The aim of this study was to assess coinfections and in-hospital mortality in a group of patients infected with HIV in Colombia.
View Article and Find Full Text PDFObjective: Insomnia is a frequent and difficult disease to treat. The objective was to determine the pharmacological management of a group of patients diagnosed with acute and chronic insomnia.
Methods: This is a cross-sectional study that identified patterns of prescription of drugs for outpatient use in patients with insomnia from a population database of 8.
Article Synopsis
- The study aimed to evaluate how timely children under 6 in Colombia received vaccinations as per the country's Expanded Immunization Program between 2014 and 2019.
- A total of 3,370,853 children were analyzed, revealing over 80% received most vaccines on time, but lower rates were noted for yellow fever (17%) and seasonal influenza (42%).
- Significant differences in vaccination timeliness were observed, particularly with indigenous children showing lower rates (65.8%) compared to the general population (78.6%), highlighting the need for targeted strategies to improve immunization access for all groups.*
Introduction: In-hospital falls are multicausal in older hospitalized patients. Drugs with anticholinergic load and psychotropic effects can increase the risk of falling.
Objective: This study aimed to determine the associations between fall risk-increasing drugs (FRIDs) and the anticholinergic risk score (ARS) with falls in hospitalized older hospitalized patients.
Objective: The incidence of falls in elderly patients in the hospital environment is three times higher than that in the community. The aim was to determine the characteristics of patients who suffered in-hospital falls and their complications.
Methods: This was a cross-sectional study with patients older than 64 years of age, admitted between 2018 and 2020 to four clinics in Colombia who presented a fall during their stay.
Introduction: Ambrisentan is a selective type A endothelin receptor antagonist that has shown significant effectiveness and safety in the management of patients with pulmonary hypertension. Its use pattern with real-world evidence in Colombia is unknown.
Objective: The objective of this study is to determine the prescription patterns of ambrisentan in some cities of Colombia.
Background: To characterize the use of sacubitril/valsartan in a group of patients with heart failure in Colombia.
Research Design And Methods: Follow-up study of patients with heart failure who started sacubitril/valsartan and were affiliated with the Colombian health system between 2019 and 2021. Sociodemographic, clinical, and pharmacological variables and adherence and persistence of use were identified.
The frequency of complications in a cohort of patients diagnosed with hemophilia A and hemophilia B receiving prophylactic treatment in Colombia: A retrospective noninterventional study.
PLoS One
November 2023
Introduction: Hemophilia A and B are disorders associated with the deficit of coagulation factors VIII and IX.
Objective: Was to determine the incidence of complications in a cohort of patients diagnosed with moderate and severe hemophilia A or B under treatment in a specialized institution.
Methods: A retrospective study of a cohort of patients with replacement therapy for hemophilia A or B, evaluating treatment and complications between January/2012 and July/2019.
Article Synopsis
- The study aimed to assess the characteristics of patients over 50 years old with fractures and evaluate the effectiveness of a Fracture Liaison Services program in Colombia, highlighting its role in reducing mortality and refracture risks.
- A total of 438 patients were analyzed, with an average age of 77.5 years; hip and vertebral fractures were the most common types, and 63.5% of the cases required surgical management.
- The program showed effective adherence to clinical guidelines, achieving a 74.6% effectiveness rate, with low rates of new falls (9.1%) and refractures (3.7%) during follow-up.
Research Objective: To identify the frequency of opioid use in a group of patients diagnosed with migraine in Colombia.
Methods: Study of a retrospective cohort of patients with a diagnosis of migraine and a first prescription of antimigraine drugs from emergency services and a priority outpatient clinic. Sociodemographic, clinical, and pharmacological variables were identified; a 12-month follow-up was carried out to identify the use of a new opioid.
This study determined the coverage and timeliness of immunization in children <6 y from Risaralda, Colombia. A retrospective cross-sectional study evaluated data from a vaccination coverage and timeliness verification survey conducted in 2019, including 2457 children <6 y from Risaralda, Colombia. Variables included demographics, a record of vaccinations included in the Colombian Vaccination Plan, and date of immunization.
View Article and Find Full Text PDFPurpose: Chronic obstructive pulmonary disease (COPD) affects approximately 174 million people worldwide. The objective was to determine the trends of COPD medication use in a group of Colombian patients.
Patients And Methods: This was a retrospective study on prescription patterns of bronchodilators and other medications used in COPD from a population database with follow-up at 12 and 24 months.
Treatment patterns of antidiabetic and kidney protective therapies among patients with type 2 diabetes mellitus and chronic kidney disease in Colombia. The KDICO descriptive study.
Diabetol Metab Syndr
July 2023
Background: Type 2 diabetes mellitus is one of the most common causes of chronic kidney disease (CKD) worldwide and prevalence of 1.75 per 100 inhabitants in Colombia. The aim of this study was to describe the treatment patterns of a group of patients with type 2 diabetes mellitus and CKD in an outpatient setting from Colombia.
View Article and Find Full Text PDFSkin and soft tissue infections are one of the main causes of consultations worldwide. The objective was to determine the treatment of a group of patients with uncomplicated skin and soft tissue infections in Colombia. Follow-up study of a cohort of patients with skin infections who were treated in the Colombian Health System.
View Article and Find Full Text PDFIntroduction: Systemic lupus erythematosus is an autoimmune disease associated with serious complications and high costs. The aim was to describe the clinical characteristics and health care resource utilization of a Colombian systemic lupus erythematosus outpatient cohort.
Methods: This was a retrospective descriptive study.
Clinical Characteristics, Patterns of Use, and incidence of Adverse Events in Patients With Nonvalvular Atrial Fibrillation Treated With Oral Anticoagulants in Colombia.
Vasc Health Risk Manag
April 2023
Article Synopsis
- The study focused on Colombian patients with non-valvular atrial fibrillation (NVAF) using oral anticoagulants, analyzing their characteristics and treatment outcomes.
- A total of 2076 patients were examined, revealing that the majority were older women with common conditions like hypertension and diabetes, with rivaroxaban being the most prescribed OA.
- While thrombotic event rates were similar between warfarin and direct oral anticoagulants, warfarin users experienced significantly more bleeding complications and had lower treatment persistence.
Background: Transdermal drug delivery has contributed positively to medical practice. However, prescriptions that do not meet minimum quality criteria and medication errors are common.
Objective: The objective was to determine how transdermal patches are being prescribed to a group of patients in Colombia, the compliance with established requirements of such prescriptions and the comparisons between correct and incorrect prescriptions.
Background: To determine the effectiveness, persistence of use, adverse reactions, interactions of orlistat and liraglutide taken for weight loss by a group of obese patients in Colombia.
Research Design And Methods: A retrospective follow-up study of a cohort of patients with obesity treated with orlistat or liraglutide. Sociodemographic, clinical, and pharmacological variables were identified.
Study of Prescription-Indication of Outpatient Systemic Anti-Fungals in a Colombian Population. A Cross-Sectional Study.
Antibiotics (Basel)
December 2022
Article Synopsis
- * Out of 74,603 patients, fluconazole was the most prescribed antifungal, often for conditions like vaginitis, while nearly 30% of prescriptions were for unapproved uses, particularly with ketoconazole.
- * Factors such as being male, under 18, living in the Caribbean, and having chronic health conditions increased the likelihood of receiving antifungals for unapproved indications, whereas having serious illnesses like diabetes or HIV decreased it.
Article Synopsis
- Chronic pain can lead to various physical and mental health issues, and during the COVID-19 pandemic, patients faced limited access to medications.
- A study analyzed the continuity of pain medication in 12,701 chronic pain patients over 18 months, revealing that 76.1% experienced treatment interruptions, especially those with oncological pain.
- The findings indicate a diverse approach to managing chronic pain, highlighting significant disruptions due to the pandemic, impacting patient care widely.
Incidence and factors related to SARS-CoV-2 infection in a cohort of patients with rheumatoid arthritis from a health service provider in Colombia during the COVID-19 pandemic.
Ther Adv Infect Dis
November 2022
Background: Patients with rheumatoid arthritis (RA) have an increased risk of SARS-CoV-2 infection due to intrinsic characteristics of the pathology and the medications used to treat it. The aim was to evaluate the incidence of and factors related to SARS-CoV-2 infection in patients with RA in Colombia.
Methods: This was an observational study of patients diagnosed with RA who were treated at a health care institution in Colombia.
Trends in the Use of Sedative-Hypnotics, Opioids, and Neuromuscular Blockers in Hospitalized Patients During the COVID-19 Pandemic: Observational Retrospective Study.
Drugs Real World Outcomes
December 2022
Background: The coronavirus disease 2019 (COVID-19) pandemic has increased the use of drugs administered for mechanical ventilation, leading to shortages in some countries.
Objective: The aim was to identify trends in the consumption of sedatives, hypnotics, neuromuscular blockers, and opioids used for anesthetic induction and deep sedation in hospitals in Colombia.
Method: This was a descriptive, longitudinal, and retrospective study with monthly follow-up of sedative, hypnotic, opioid, and neuromuscular blocker dispensing in 20 clinics and hospitals from January to November 2020.
Satisfaction with and Use of Inhalation Devices in Patients with Bronchial Asthma.
J Aerosol Med Pulm Drug Deliv
December 2022
Greater patient satisfaction with his or her inhalation device is associated with better adherence to pharmacological therapy and better clinical outcomes, such as improved quality of life, greater asthma control, and fewer exacerbations. The objective of this study was to determine the satisfaction level of a group of patients diagnosed with bronchial asthma concerning their devices for inhalation of bronchodilators and glucocorticoids. This was a cross-sectional study of patients treated in the Colombian health system.
View Article and Find Full Text PDF