Publications by authors named "Manuel Javier Munoz"

Enterohemorrhagic (EHEC) strains are food-borne pathogens that can cause different clinical conditions. Shiga toxin 2a and/or 2c (Stx2)-producing O157:H7 is the serotype most frequently associated with severe human disease. In this work we analyzed the hypothesis that host cells participate in Stx2 production, cell damage, and inflammation during EHEC infection.

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Article Synopsis
  • Heterogeneous nuclear ribonucleoprotein (hnRNP) K is crucial for the p53 DNA damage response, acting as a co-factor for p53 and is regulated by ubiquitin and SUMO modifications.
  • SUMO is added to hnRNP K at lysine 422, and its conjugation is controlled by the E3 ligase Pc2/CBX4, increasing in response to DNA damage.
  • The SUMO modification of hnRNP K is necessary for proper p53 transcriptional activation, particularly affecting the regulation of the p53 target gene p21.
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