Climate forcing on estuarine zooplanktonic production.

Estuaries are among the most valuable aquatic systems in the world and resolving how there are impacted by climate change is fundamental to their management under global change scenarios. In this study, a ten-year time series (2003-2013) of zooplankton in an estuarine area (Mondego estuary, Portugal) is used to determine the impact of climate variability on estuarine zooplanktonic secondary production. For that, a trend analysis of seasonal zooplankton production was applied and their link with large-scale, regional, and local environment was tested by Distance-based multivariate multiple regression (DistLM).

Development of a Prognostic Nomogram for Liver Metastasis of Uveal Melanoma Patients Selected by Liver MRI.

Patients with liver metastases of uveal melanoma (LMUM) die from their metastatic evolution within 2 years. We established a nomogram to choose a treatment adapted to life expectancy. From 2002 to 2013, we reviewed 224 patients with LMUM selected by liver MRI.

Selumetinib in Combination With Dacarbazine in Patients With Metastatic Uveal Melanoma: A Phase III, Multicenter, Randomized Trial (SUMIT).

Purpose Uveal melanoma is the most common primary intraocular malignancy in adults with no effective systemic treatment option in the metastatic setting. Selumetinib (AZD6244, ARRY-142886) is an oral, potent, and selective MEK1/2 inhibitor with a short half-life, which demonstrated single-agent activity in patients with metastatic uveal melanoma in a randomized phase II trial. Methods The Selumetinib (AZD6244: ARRY-142886) (Hyd-Sulfate) in Metastatic Uveal Melanoma (SUMIT) study was a phase III, double-blind trial ( ClinicalTrial.

[Can medical oncologists talk about cure to their patient after localized breast cancer treatment?].

Introduction: Despite ongoing therapeutic advances in oncology, the use of the term cure in front of patients remains controversial. The word remission is often preferred in clinical practice. The purpose of this research is to explore how oncologists vary in their usage and definition of the word cure when talking to patients.

Resonantly Increased Optical Frequency Conversion in Atomically Thin Black Phosphorus.

Optical frequency conversion via the nonlinear effect of third harmonic generation is shown to be resonantly enhanced in few-layer black phosphorus. This feature is believed to be a consequence of exciton-related resonance, as the enhancement is strongly correlated with the observation of exciton-recombination photoluminescence. Few-layer thicknesses are obtained both via mechanical exfoliation and laser thinning.

[Targeted therapy in locally and metastatic recurrent cervical cancers].

Doublet chemotherapy with cisplatin is the reference for the treatment of recurrent cervical cancer. However, those tumors are little chemo-sensitive and overall survival remains poor. Moreover, because of pelvic irradiation, toxicities, especially hematologic toxicities, are increased and require a drug dose reduction.

Genome-wide profiling is a clinically relevant and affordable prognostic test in posterior uveal melanoma.

Objective: This study investigated the capacity of genetic analysis of uveal melanoma samples to identify high-risk patients and discusses its clinical implications.

Methods: Patients with posterior uveal melanoma were prospectively enrolled. Tumour samples were derived from enucleated globe, fine-needle aspirates or endoresection.

Genomic amplification is not a frequent event in uveal melanomas.

This Correspondence relates to the article by Lake et al that reported copy number and genotyping analysis on formalin-fixed, paraffin-embedded samples using genome-wide SNP arrays version 6.0.

[Role of high-throughput sequencing in oncology].

New sequencing technologies are one of the most important technical advances in biology in the last 10 years. These technologies allow sequencing millions of DNA fragments in parallel, covering billions of bases in a short period of time. These techniques allowed discovering millions of variants, which functional and clinical value rest yet to be confirmed.

Sorafenib exposure decreases over time in patients with hepatocellular carcinoma.

Background: Intra-patient variability in sorafenib pharmacokinetics has been poorly investigated to date. We hypothesized that sorafenib clearance could decrease over time, as seen with imatinib.

Patients And Methods: Sorafenib plasma concentrations were determined by liquid chromatography, every 2 weeks, in consecutive hepatocellular carcinoma patients treated with sorafenib.

Lobular invasive carcinoma of the breast is a molecular entity distinct from luminal invasive ductal carcinoma.

In order to get insight into the molecular alterations of invasive lobular carcinoma (ILC), comparative genomic hybridisation array and transcriptomic analyses of a series of 62 oestrogens-positive (ER) invasive tumours [21 ILC and 41 invasive ductal carcinomas (IDC)] were performed. ILC and IDC shared highly recurrent regions of gains (1q12-q44(+) in more than 60% of the cases, 16pter-p11.2(+) in 45% and 63% of ILC and IDC, respectively) and losses (16q11.

[Role of antioxidant complements and supplements in oncology in addition to an equilibrate regimen: a systematic review].

Eating fruits and vegetables reduces risk of cancer by about 30%, however the active anticarcinogenic components of food remain to be determined. The well known oncogenic potential of oxidative stress have led to the use of antioxidants, contain in high proportions in fruits and vegetables, as cancer prevention. Numerous observational and interventional studies allowed to observe conflicting results.