Ischemic heart disease is a major global health concern, and the study explores a new collagen hydrogel that can effectively deliver SDF1 to support heart recovery post-myocardial infarction.
The bilayer collagen-on-collagen scaffold shows strong suture strength and compatibility with heart tissue, promoting the delivery of therapeutic growth factors while avoiding cytotoxic effects.
In animal experiments, this scaffold not only integrated well into the heart but also improved cardiac function and reduced tissue stiffness, indicating its potential as a treatment for heart remodeling after injury.